REAL-TIME DIAGNOSTIC SYSTEM EMPLOYING NON-INVASIVE METHOD TO ANALYZE ELECTRO-MAGNETIC FIELD RADIATED FROM A SUBJECT AND THE VARIATION THEREOF

• US 20090137895A1
• Filed: 03/02/2007
• Published: 05/28/2009
• Est. Priority Date: 03/02/2006
• Status: Active Application

• Current Assignee: XTend Medical Corporation
• Original Assignee: XTend Medical Corporation
• Inventors: LEE, Sang-Moon
• Application Number:
  US12/280,766
• Publication Number:
  US 20090137895A1
• Time in Patent Office: Days
• US Class Current: 600/407
• CPC Class Codes: A61B 5/05 Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves impedance plethysmography A61B5/0295; measuring movement of the entire body or parts thereof A61B5/11; detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof A61B5/24

Abstract

The present invention relates to a real-time disease diagnostic system employing a non-invasive method capable of analyzing of an electromagnetic field and variations thereof radiated from a subject. The disease diagnostic system detects a micro electromagnetic field and variations thereof radiated from bio-action potential of the living tissue, such as cells, tissues, organs and the like of a subject, as a capacitance and variations thereof using a single- or multi-channel biosensor and the disease diagnostic system including the biosensor. The disease diagnostic system analyzes the frequency obtained according to the capacitance and variations thereof and diagnoses proliferative diseases characteristic of an abnormal cell proliferation by diagnosing whole body using a non-invasive method in a short time of 10 min to 1 hour without any side effects. The disease diagnostic system displays the result of diagnosis in the form of a numerical value, sound or three-dimensional image in real time. The disease diagnosis system may be used without any of the doctor'"'"'s orders for the subject, i.e., an empty stomach or taking medicine, and used to easily confirm the removal of cancer cell by surgery and the process of treatment. Therefore, the disease diagnosis system can be useful to diagnose various diseases at an early stage in a more accurate and safe manner.

Claims

1. A real-time disease diagnostic system employing a non-invasive method by analyzing an electromagnetic field, and variations thereof, radiated from a subject, the system comprising:

a sensor probe 1 comprising at least one biosensor-receiving a biological electro-magnetic field in a living organism including a human body and changing a capacitance;

an analog circuit 2 for processing a bio-action potential signal measured by the sensor probe 1 into an analog signal;

a digital conversion circuit 3 for converting the analog signal outputted from the analog circuit 2 into digital signal and processing the digital signal; and

a power circuit 4 for supplying driving power to the system and charging a battery with power, a communication circuit for communicating with a PC, and a communication module 19 for wireless communication with a PC.

2. The system according to claim 1, wherein the analog circuit 2 comprises:

a multi-channel multiplexer 22 for selecting a channel from the sensor probe 1;

a sensor selection unit 23 for selecting specific sensors among multi-channel sensors from the sensor probe 1 and selecting a sensor for measurement from the specific sensors;

a frequency controller 24 for minimizing errors such as an error caused when a region of the biosensors of the sensor probe 1 is composed of multiple channels, a basic manufacturing error of electronic components, and an environmental error of a measurement region and the like and adjusting a frequency generated in a frequency oscillation circuit 20 to a reference frequency of the sensor accurately;

a frequency generator 25 for generating a reference frequency unique to the sensors based on the capacitance element when the biosensors in the sensor probe 1 is in a normal state before their diagnosis;

a frequency signal amplifier 26 for amplifying level of a frequency signal generated from the frequency generator 25 up to a level where the frequency signal can be in the digital conversion circuit 3; and

a frequency allocator 27 for allocating the frequency to be measured in the digital conversion circuit 3.

3. The system according to claim 1, wherein the digital conversion circuit 3 comprises:

a flash memory 12 for storing measurement data and program data;

a SDRAM 13 used for a temporary memory area;

a CPU 11 for measuring the frequency and performing various operations;

a PWM module 16 comprising a switch circuit receiving a command from a user and a buzzer 16b generating sounds according to an input frequency;

a LCD 15 for operating measured data and displaying the operated data on a graphic user interface (GUI); and

a LCD inverter 14 for controlling a brightness of the LCD 15.

4. The system according to claim 1, wherein the power circuit 4 is free from the use of power supplied from a commercial power source, the power is supplied from a battery 34 even though an adaptor 31 is used for connection, and

wherein the power circuit 4 is configured to feed back a voltage of the battery 34 to the CPU 11 by a battery charge measurement circuit 32 in order to check a residual capacity and charged capacity of the battery 34 and residual capacity of battery.

5. The system according to claim 2, wherein the frequency signal amplifier 26 converts a level of a frequency signal outputted through a RLC circuit in the frequency generator 25 up to a level where the frequency signal can be measured in the digital conversion circuit 3.

6. The system according to claim 1, wherein the basic capacitance of the biosensor is in a range from 0.5 pF to 900 pF.

7. The system according to claim 6, wherein a frequency of an oscillating circuit is determined according to the changes in the capacitance of the biosensor.

8. The system according to claim 1, wherein a value of the capacitance is converted into a frequency or a voltage value for diagnosing a disease of the subject, wherein the capacitance is changed according to a value of the bio-action potential detected and inputted by the biosensor from a living tissue of the subject.

9. The system according to claim 1, wherein the health condition of the subject is determined according to a variation of a delta frequency which is a difference value between the reference frequency unique to the biosensor and the measured frequency detected by the biosensor.

10. The system according to claim 9, wherein the difference value between the reference frequency and the measured frequency is determined by determining a delta frequency using a clock of the CPU 11 supplied through an oscillator 10 and a voltage-frequency (VF) converter, measuring the frequency oscillated from the sensor, and comparing the measured frequency with the reference frequency.

11. The system according to claim 9, wherein the difference value between the reference frequency and the measured frequency is determined by converting a voltage value into a digital value and comparing the measured frequency with the reference frequency, the voltage value being obtained by passing the frequency outputted from the sensor through a frequency-voltage (FV) converter using an A/D converter inside or outside of the CPU 11 in measuring the frequency oscillated from the sensor.

12. The system according to claim 9, wherein the reference frequency is a reference frequency for comparing with the measured frequency detected by the biosensor when the biosensor is free from the exposure to the bio-action potential, and which is adjusted to the same frequency as the frequency unique to the biosensor.

13. The system according to claim 12, wherein the reference frequency of the sensor as the frequency unique to the biosensor has a frequency band range from 0.5 Hz to 95 MHz.

14. The system according to claim 13, wherein the reference frequency is primarily calibrated in the analog circuit and secondarily adjusted to the same frequency as the frequency unique to the biosensor by the digital conversion circuit and a given program, in consideration of the characteristics of the biosensor sensitive to measurement environments.

15. The system according to claim 14, wherein the reference frequency that can be adjusted by an analog mode is in a range from 5 Khz to 10 Mhz.

16. The system according to claim 14, wherein the reference frequency that can be adjusted by a digital mode is in a range from 0.1 hz to 1 Mhz.

17. The system according to claim 5, wherein an acquisition speed of the value of bio-action potential inputted from the biosensor to be changed by the digital mode.

18. The system according to claim 9, wherein the health condition of the subject is classified into three types or more according to the measured value of the delta frequency, which are represented by green, yellow, red color, or other diverse color indicators, respectively.

19. The system according to claim 9, wherein the health condition of the subject is classified into three types or more according to the measured value of the delta frequency which is shown in color as green, yellow, red color, or other diverse color indicators, respectively, and, in the case of the subject suffering from cancer, the yellow and red indicators are irregularly displayed on an LCD screen and displayed on a screen of a monitor of the PC to which data measured by the measurement device is transmitted.

20. The system according to claim 16, wherein the health condition of the subject is classified into three types or more according to the measured value of the delta frequency which is shown in color as green, yellow, red color, or other diverse color indicators, respectively, and boundary values among green, yellow, red color and other various colors is controlled according to the purpose of use.

21. The system according to claim 9, wherein the health condition of the subject is classified into multiple types according to the measured value of the delta frequency which is shown in color as a sound signal or an alarm sound having the frequency different from one another.

22. The system according to claim 1, wherein the disease diagnostic system is connected with the PC by means of a wireless LAN, a wireless communication module, a USB port or RS-232C, and the PC program the data measured by the disease diagnostic system in the form of a three-dimensional graphic, multi-dimensional graphic or stereoscopic image.

23. The system according to claim 1, wherein the disease diagnostic system is connected with the PC by means of a wireless LAN, a wireless communication module, a USB port or RS 232C, and the PC stores the data measured by the disease diagnostic system into the database.

24. The system according to claim 17, wherein the health condition of the subject is classified into three types or more according to the measured value of the delta frequency which is shown in color as green, yellow, red color, or other diverse color indicators, respectively, and boundary values among green, yellow, red color and other various colors is controlled according to the purpose of use.