Apparatus and Methods for Repetitive Microjet Drug Delivery

• US 20090137926A1
• Filed: 02/05/2009
• Published: 05/28/2009
• Est. Priority Date: 04/21/2003
• Status: Abandoned Application

• Current Assignee: Corium International, Inc.
• Original Assignee: Corium International, Inc.
• Inventors: Rathnasingham, Ruben, Arkilic, Errol Bernard, Srinivasan, Ravi
• Application Number:
  US12/366,091
• Publication Number:
  US 20090137926A1
• Time in Patent Office: Days
• US Class Current: 600/562
• CPC Class Codes: A61M 15/008 Electronic counters
• CPC Class Codes: A61M 15/025 Bubble jet droplet ejection devices
• CPC Class Codes: A61M 2005/3022 Worn on the body, e.g. as patches pressure infusion of the skin patch type A61M5/14248
• CPC Class Codes: A61M 2205/13 with means for the detection of operative contact with patient, e.g. lip sensor
• CPC Class Codes: A61M 37/0015 by using microneedles
• CPC Class Codes: A61M 5/14248 of the skin patch type
• CPC Class Codes: A61M 5/204 connected to external reservoirs for multiple refilling
• CPC Class Codes: A61M 5/30 Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
• CPC Class Codes: A61M 5/46 having means for controlling depth of insertion

Abstract

An active, transdermal delivery system includes a support structure and a fluid reservoir within the support structure configured to contain a fluid to be delivered transdermally. There is also at least one exit orifice defined in the support structure that is in communication with the fluid reservoir. The orifice has a diameter of between about 1 μm and 500 μm. Furthermore, a repeatable activation means is disposed within the support structure and is in cooperation with the exit orifice for ejection of fluid in response to an activation signal.

Claims

1. A method for active, transdermal delivery, comprising:

positioning a support structure defining an orifice adjacent a biological tissue, said orifice having a diameter of between about 1 μ

m and about 500 μ

m, and said support structure in fluid communication with a fluid to be administered to the biological tissue; and

actively and repetitively ejecting fluid into the biological tissue.

2. The method of claim 1, further comprising, before said positioning, programming a controller with a sustained administration regime according to a substance to be delivered and a patient'"'"'s needs.

3. The method of claim 1, further comprising, during active and repetitive ejection of said fluid, recording administration data and associated patient data throughout an administration regime.

4. The method of claim 3, further comprising interfacing with the controller to retrieve the administration data during the administration regime.

5. The method of claim 2, further comprising interfacing with the controller to change the administration regime.

6. The method of claim 1, wherein said fluid includes an analyte for performing a diagnosis on a biological system of said biological tissue.

7. The method of claim 1, further comprising, after actively and repetitively ejecting the fluid, extracting fluid from said biological tissue for analysis.

8. The method of claim 1, wherein said actively and repetitively ejecting fluid into the biological tissue is configured to disrupt a stratum corneum of an epithelial tissue such that biological fluid below the stratum corneum can be removed from said biological tissue.