METABOLIC REGULATORS AND USES THEREOF
First Claim
1. A method of modulating a metabolic function in a subject, the method comprising administering to a subject an effective amount of a pharmaceutical composition comprising an agent that affects the activity and/or expression of metabolic regulator, wherein the metabolic regulator is selected from the group of MSP1, MPS2, MPS3, MPS4, MPS5 or Ins16 or homologues thereof, or their expression product or functional fragments thereof, and changing the expression of the metabolic regulator or its level in a cell modulates at least one metabolic function.
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Abstract
The present invention relates to metabolic regulators that affect metabolic function, for example metabolic regulators that affect muscle mass, muscle regeneration, muscle hypertrophy, fat mass, insulin and glucose sensitivity, angiogenesis and cardiovascular function. In particular, the present invention relates to modulating metabolic function by administering an effective amount of a pharmaceutical composition comprising an agent, where the agent activates or inhibits the activity and/or gene expression of the metabolic regulator. The metabolic regulators of the present invention are, for example MSP1 (2160028F08Rik; SEQ ID NO: 16); MSP2 (2310043I08Rik; SEQ ID NO: 17); MSP3 (NM_026754;1 110017116Rik; SEQ ID NO: 1); MSP4 (4732466D17Rik; SEQ BD NO: 18); MSP 5 (NM_024237; 1600015H20Rik; SEQ ID NO: 12); Ins16 (AF_156094; SEQ ID NO: 20). The present invention also provides methods to screen for agents that affect the metabolic regulators of the present invention.
24 Citations
34 Claims
- 1. A method of modulating a metabolic function in a subject, the method comprising administering to a subject an effective amount of a pharmaceutical composition comprising an agent that affects the activity and/or expression of metabolic regulator, wherein the metabolic regulator is selected from the group of MSP1, MPS2, MPS3, MPS4, MPS5 or Ins16 or homologues thereof, or their expression product or functional fragments thereof, and changing the expression of the metabolic regulator or its level in a cell modulates at least one metabolic function.
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27-33. -33. (canceled)
Specification