B7-H4 RECEPTOR AGONIST COMPOSITIONS AND METHODS FOR TREATING INFLAMMATION AND AUTO-IMMUNE DISEASES
First Claim
1. A pharmaceutical composition comprising a B7-H4 receptor agonist in an amount effective to inhibit or reduce one or more symptoms of an inflammatory response or autoimmune disease or disorder.
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Accused Products
Abstract
Compositions containing B7-H4 receptor agonists in an amount effective to reduce, inhibit, or mitigate an inflammatory response in an individual and methods for the treatment or prophylaxis of inflammatory disorders and autoimmune diseases or disorders have been developed. It has been discovered that B7-H4 receptor agonists, for example B7-H4 fusion proteins function as an agonist of the B7-H4 receptor on T cells to suppress both humoral and cellular autoimmunity activity. In one embodiment, B7-H4 fusion proteins compete with sH4 for a common receptor on T cells.
92 Citations
16 Claims
- 1. A pharmaceutical composition comprising a B7-H4 receptor agonist in an amount effective to inhibit or reduce one or more symptoms of an inflammatory response or autoimmune disease or disorder.
- 9. A method for treating or inhibiting one or more symptoms of an inflammatory response in an individual in need thereof comprising administering to the individual a B7-H4 receptor agonist in an amount effective to reduce or inhibit the one or more symptoms of the inflammatory response in the individual.
Specification