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CONTROL OF DRUG RELEASE BY TRANSIENT MODIFICATION OF LOCAL MICROENVIRONMENTS

  • US 20090142386A1
  • Filed: 02/09/2009
  • Published: 06/04/2009
  • Est. Priority Date: 01/25/2005
  • Status: Abandoned Application
First Claim
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1. A method for inhibiting the gelation, aggregation, or precipitation of a drug released from a reservoir in an implanted drug delivery device comprising:

  • providing a drug which has limited solubility or tends to undergo gelation, aggregation, or precipitation at a physiological pH at a site at which said drug delivery device is to be implanted; and

    formulating the drug in a dry solid form with a release-modifying agent within said reservoir;

    opening said reservoir to permit the physiological fluid to solubilize the drug, wherein the release modifying agent is present in an amount effective to changes the pH of a microenvironment in or about the reservoir in an amount effective to inhibit gelation, aggregation, or precipitation of the drug, whereby the solubilized drug can be released from the implanted drug delivery device.

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