Needle-to-Needle Electrospinning

• US 20090142505A1
• Filed: 11/20/2008
• Published: 06/04/2009
• Est. Priority Date: 11/30/2007
• Status: Active Grant

• Current Assignee: Cook Medical Technologies, LLC (Cook Group Incorporated)
• Original Assignee: Cook Incorporated (Cook Group Incorporated), MED Institute, Inc. (Cook Group Incorporated)
• Inventors: Moore, William F., Orr, David E.
• Granted Patent: US 7,799,261 B2
• Time in Patent Office: Days
• US Class Current: 427/458
• CPC Class Codes: B05B 5/0255 spraying and depositing by electrostatic forces only
• CPC Class Codes: B05B 5/08 Plant for applying liquids or other fluent materials to objects
• CPC Class Codes: B05B 5/087 Arrangements of electrodes, e.g. of charging, shielding, collecting electrodes B05B5/12, B05B5/14 take precedence; arrangements of electrodes on the discharge apparatus B05B5/0533
• CPC Class Codes: B05B 5/12 specially adapted for coating the interior of hollow bodies
• CPC Class Codes: B05D 1/04 involving the use of an electrostatic field B05D1/025 and B05D1/14 take precedence
• CPC Class Codes: B05D 2252/10 Applying the material on both sides
• CPC Class Codes: B05D 2254/02 Applying the material on the exterior of the tube
• CPC Class Codes: B05D 2254/04 Applying the material on the interior of the tube
• CPC Class Codes: D01D 5/0061 characterised by the electro-spinning apparatus
• CPC Class Codes: D01D 5/0084 Coating by electro-spinning, i.e. the electro-spun fibres are not removed from the collecting device but remain integral with it, e.g. coating of prostheses

Abstract

The disclosure relates to a method and apparatus for coating a medical device. The method includes providing an electrospinning apparatus and simultaneously electrospinning at least one solution onto a first surface and an opposing second surface. The apparatus comprises a first spinneret and a second spinneret. An energy source is electrically coupled to the first spinneret and the second spinneret. The first spinneret and second spinneret comprise a reservoir and an orifice fluidly coupled to the reservoir. The first spinneret orifice is located substantially opposite the second spinneret orifice.

Claims

1. A method for preparing a substrate comprising:

providing an electrospinning apparatus;

simultaneously electrospinning at least one solution onto both a first surface and an opposing second surface.

2. The method of claim 1, where the at least one solution comprises at least one material selected from the group comprising polymers, proteins, bioadhesives, and bioactive agents.

3. The method of claim 1, where the electrospinning apparatus comprises a first orifice and a second orifice and further comprising locating the first orifice substantially opposite the second orifice.

4. The method of claim 3, where the first orifice is fluidly coupled to a first solution and the second orifice is fluidly coupled a second solution.

5. The method of claim 4, where the first solution is different from the second solution.

6. The method of claim 3, further comprising moving the first surface and opposing second surface relative to the first spinneret or second spinneret.

7. A method for preparing a medical device comprising:

providing a medical device and an electrospinning apparatus;

the medical device comprising a first surface and an opposing second surface;

the electrospinning apparatus comprising a first spinneret and a second spinneret located substantially opposite the first spinneret;

the first spinneret comprising a reservoir loaded with a first solution and an orifice fluidly coupled to the reservoir;

the second spinneret comprising a reservoir loaded with a second solution and an orifice fluidly coupled to the reservoir;

locating the first spinneret orifice nearby the medical device first surface;

locating the second spinneret orifice nearby the medical device second surface;

simultaneously electrospinning the first solution onto the medical device first surface and the second solution onto the medical device second surface.

8. The method of claim 7 where the electrospinning apparatus further comprises an energy source electrically coupled to the first spinneret and the second spinneret and further comprising applying a first electrical charge with the energy source to the first spinneret and applying a second, opposing electrical charge with the energy source to the second spinneret.

9. The method of claim 7, further comprising locating the first spinneret orifice substantially opposite the second spinneret orifice.

10. The method of claim 7, where the first solution and second solution comprise at least one material selected from the group comprising polymers, proteins, bioadhesives, and bioactive agents

11. The method of claim 10, where the first solution is different from the second solution.

12. The method of claim 7, further comprising moving the medical device relative the first spinneret orifice or second spinneret orifice and simultaneously electrospinning the first solution about a length or width of the medical device first surface and the second solution about a length or width of the medical device second surface.

13. The method of claim 7, where the medical device further comprises a lumen, and further comprising locating the second spinneret orifice in the medical device lumen.

14. An electrospinning apparatus comprising:

a first spinneret comprising a reservoir and an orifice fluidly coupled to the reservoir;

a second spinneret comprising a reservoir and an orifice fluidly coupled to the reservoir;

an energy source electrically coupled to the first spinneret and the second spinneret;

where the first spinneret orifice is located substantially opposite the second spinneret orifice.

15. The apparatus of claim 14, further comprising a first solution loaded into the first spinneret reservoir and a second solution loaded into the second spinneret reservoir.

16. The apparatus of claim 15, where the first solution and second solution comprise at least one material selected from the group comprising polymers, proteins, bioadhesives, and bioactive agents.

17. The apparatus of claim 16, where the first solution is different from the second solution.

18. The apparatus of claim 14, where the first spinneret further comprises a first electrical charge and the second spinneret further comprises a second, opposing electrical charge.

19. The apparatus of claim 14, where the first spinneret further comprises a fluid displacement system and where the second spinneret further comprises a fluid displacement system.

20. The apparatus of claim 14, where the first spinneret and second spinneret comprise a helical or hemispherical configuration.