Methods for Administering Aripiprazole
First Claim
1. An injectable composition for the extended release of aripiprazole comprising a mixture of at least about 10 mg/ml aripiprazole in an injection vehicle comprising an optional viscosity enhancing agent.
6 Assignments
0 Petitions
Accused Products
Abstract
The present invention relates, in part, to the discovery that a pharmaceutical composition comprising aripiprazole and a carrier administered in a bolus injection resulted in an extended release profile similar to that obtained by the injection of a poly lactide-co-glycolide microsphere formulation containing the active agent. This surprising result suggests that pharmacologically beneficial extended release formulations without the complexities and expense associated with the manufacture microspheres.
42 Citations
39 Claims
- 1. An injectable composition for the extended release of aripiprazole comprising a mixture of at least about 10 mg/ml aripiprazole in an injection vehicle comprising an optional viscosity enhancing agent.
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4-5. -5. (canceled)
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8-9. -9. (canceled)
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14. (canceled)
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15. A composition comprising at least about 10 mg of aripiprazole and an aqueous injection vehicle comprising water, a viscosity enhancing agent, a wetting agent and a tonicity agent.
- 16. A composition comprising at least about 10 mg of aripiprazole and an aqueous injection vehicle comprising water, about 3% by volume carboxymethylcellulose, about 0.1% polysorbate 20 and about 0.9% by weight to about 1% by weight sodium chloride.
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17. (canceled)
- 18. A method for providing aripiprazole to an individual in an extended release injectable composition comprising administering a mixture of at least about 10 mg/ml aripiprazole in an injection vehicle comprising an optional viscosity enhancing agent.
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19. (canceled)
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21. (canceled)
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24-25. -25. (canceled)
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28-29. -29. (canceled)
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34. (canceled)
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36. (canceled)
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38. (canceled)
Specification