Anesthetic composition, formulation and method of use

• US 20090143436A1
• Filed: 11/06/2008
• Published: 06/04/2009
• Est. Priority Date: 11/06/2007
• Status: Abandoned Application

• Current Assignee: Stuart L. Weg
• Original Assignee: Stuart L. Weg
• Inventors: Weg, Stuart L.
• Application Number:
  US12/291,343
• Publication Number:
  US 20090143436A1
• Time in Patent Office: Days
• US Class Current: 514/330
• CPC Class Codes: A61K 31/137 Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
• CPC Class Codes: A61K 31/167 having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
• CPC Class Codes: A61K 31/445 Non condensed piperidines, e.g. piperocaine
• CPC Class Codes: A61K 38/47 acting on glycosyl compounds (3.2), e.g. cellulases, lactases
• CPC Class Codes: A61K 9/0019 Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner non-active ingredients are additionally classified in A61K47/00
• CPC Class Codes: A61M 2202/048 Anaesthetics
• CPC Class Codes: A61M 5/19 having more than one chamber , e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly surgical glue applicators A61B17/00491
• CPC Class Codes: A61M 5/2448 comprising means for injection of two or more media, e.g. by mixing
• CPC Class Codes: A61P 23/00 Anaesthetics
• CPC Class Codes: A61P 25/04 Centrally acting analgesics, e.g. opioids
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: C12Y 302/01035 Hyaluronoglucosaminidase (3.2.1.35), i.e. hyaluronidase

Abstract

An anesthetic composition for use e.g. in the administration of a local anesthetic by injection comprises a first component, which comprises hyaluronidase, and a second component which comprises an anesthetic preparation. The composition is both effective and highly shelf stable, and has as an advantage that it may be stored and administered at room temperature. In a particular embodiment, the hyaluronidase is prepared in dry powder form, as by lyophilization. The anesthetic component may be selected from a group of known anesthetics, such as lidocaine, polocaine, xylocaine, novocaine, procaine, prilocaine, bupivacaine, mepivacaine, carbocaine, etidocaine and chincocaine. The composition may be prepared in unit dosage forms, including a single dosage form, for a variety of purposes, and such unit dosage forms may be prepared in a plural chambered syringe or like dispenser, whereby the components are not mixed until administration.

Claims

1. An anesthetic composition having improved efficacy and room temperature shelf-stability comprising a first component serving as an adjuvant, and a second component comprising an anesthetic formulation,

said first and said second components being segregated from contact with each other until use,

said first component comprising a shelf stable preparation of hyaluronidase, and said second component comprising an anesthetic selected from the group consisting of lidocaine, marcaine, polocaine, xylocaine, novocaine, procaine, prilocaine, bupivacaine, mepivacaine, carbocaine, etidocaine and chincocaine.

2. A composition according to claim 1 wherein said components are mixed at the time of administration.

3. A composition according to claim 1 wherein said hyaluronidase in prepared in a powdered form.

4. A composition according to claim 3 wherein said hyaluronidase is prepared in a powdered form by lyophilization.

5. A composition according to claim 1 wherein said anesthetic comprises a mixture of lidocaine and marcaine.

6. A composition according to claim 1 wherein said anesthetic comprises a mixture of lidocaine and epinephrine.

7. A composition according to claim 1 wherein said anesthetic comprises a mixture of lidocaine and bupivicaine.

8. A composition according to claim 1 wherein said anesthetic comprises lidocaine.

9. A composition according to claim 8 wherein said anesthetic is prepared in a solution having a concentration ranging from 1.0% to about 5.0% by weight of active ingredient.

10. A unit dosage form for the administration of an anesthetic by injection, comprising the composition of claim 1 prepared in a quantity of 4 cc for use as an anesthetic block.

11. The unit dosage form of claim 10 wherein said composition is disposed within a syringe having plural cavities each containing one of said components, whereby the operation of the syringe to dispense said composition will cause the mixing of the said components prior to dispensing, as by injection.

12. The unit dosage form of claim 10 prepared as a single dosage form.

13. A method for the administration of the anesthetic composition of claim 1 comprising the preparation of a dispensing device with a unit dosage form according to claim 11, and the operation of said syringe to dispense said composition at the intended site for anesthesia.