Apparatus, System and Method for Determining Cardio-Respiratory State

• US 20090143655A1
• Filed: 01/30/2007
• Published: 06/04/2009
• Est. Priority Date: 01/30/2006
• Status: Abandoned Application

• Current Assignee: CardioSense, Ltd.
• Original Assignee: CardioSense, Ltd.
• Inventors: Shani, Haim
• Application Number:
  US11/992,921
• Publication Number:
  US 20090143655A1
• Time in Patent Office: Days
• US Class Current: 600/323
• CPC Class Codes: A61B 5/0059 using light, e.g. diagnosis by transillumination, diascopy, fluorescence A61B5/0093, A61B5/1455, A61B5/02416 and A61B5/0261 take precedence
• CPC Class Codes: A61B 5/02241 of small dimensions, e.g. adapted to fingers
• CPC Class Codes: A61B 5/02416 using photoplethysmograph signals, e.g. generated by infrared radiation A61B5/14552 takes precedence
• CPC Class Codes: A61B 5/413 Monitoring transplanted tissue or organ, e.g. for possible rejection reactions after a transplant
• CPC Class Codes: A61B 5/441 Skin evaluation, e.g. for skin disorder diagnosis

Abstract

An apparatus, system and method provide data indicative of cardio-respiratory state of a patient. Two or more cardio-respiratory parameters of the patient are measured, and optionally monitored over time, the two or more cardio-respiratory parameters being different one from the other and being measured at a same anatomical part of said patient.

Claims

1-76. -76. (canceled)

77. Apparatus for providing data indicative of cardio-respiratory state of a patient, the apparatus comprising at least two cardio-respiratory sensor modules for providing at least two cardio-respiratory parameters, including:

—

first sensor module for measuring a first cardio-respiratory parameter of said patient, wherein said first cardio-respiratory parameter is capillary refill time (CRT);

second sensor module for measuring a second cardio-respiratory parameter of said patient, different from said first cardio-respiratory parameter, wherein said second cardio-respiratory parameter is any one of blood oxygenation state, a peripheral perfusion parameter (PU) other than capillary refill time, blood pressure, pulse rate, systemic vascular resistance;

wherein said apparatus is adapted for measuring said first cardio-respiratory parameter and said second cardio-respiratory parameter at a same anatomical part of said patient.

78. Apparatus according to claim 77, wherein said apparatus further comprises a third cardio-respiratory sensor module for measuring at said same anatomical part at least one third cardio-respiratory parameter of said patient different from said first or second cardio-respiratory parameters.

79. Apparatus according to claim 78, wherein said apparatus further comprises a fourth cardio-respiratory sensor module for measuring at said same anatomical part at least one fourth cardio-respiratory parameter of said patient different from said first, second or third cardio-respiratory parameters.

80. Apparatus according to claim 78, wherein each said cardio-respiratory sensor is configured for monitoring a different one of any of the following cardio-respiratory parameters:

capillary refill time (CRT);

a peripheral perfusion parameter other than CRT;

blood oxygenation level;

blood pressure;

pulse rate;

systemic vascular resistance.

81. Apparatus according to claim 79, wherein each said cardio-respiratory sensor is configured for monitoring a different one of any of the following cardio-respiratory parameters:

capillary refill time (CRT);

a peripheral perfusion parameter other than CRT;

blood oxygenation level;

blood pressure;

pulse rate;

systemic vascular resistance.

82. Apparatus according to claim 77, wherein at least two said cardio-respiratory sensors are configured for measuring corresponding cardio-respiratory parameters with respect to a common vascular bed on said same anatomical part.

83. Apparatus according to claim 77, wherein said first cardio-respiratory sensors comprises a CRT sensor module configured for monitoring a capillary refill time (CRT), said CRT sensor module comprising:

i) means for illuminating a skin area comprised in said same anatomical part to be gauged for wavelength with a light from a light source;

ii) means for filtering out background noises and light to obtain a base-line measurement; and

iii) means for comparing the wavelength of light received from the skin area with the base-line measurement, thereby determining the filling time of blood vessels in said area.

84. Apparatus according to claim 77, wherein said first cardio-respiratory sensors comprises a CRT sensor module configured for monitoring a capillary refill time (CRT), said CRT sensor comprising:

i) a light source for illuminating a skin area of the patient'"'"'s skin overlying blood vessels with light at a first wavelength, said skin area having an original color, a light sensor for intercepting light at a second wavelength obtained from said skin area or at a depth within said skin area and generating a first signal having a magnitude which corresponds to the second wavelength, said second wavelength representing a level of reflection from blood vessels subjacent said skin area;

ii) a filter for filtering said first electrical signal and for rejecting unwanted electrical signals originating in interfering light, and for producing a second signal, whose amplitude is proportional to the amplitude of said filtered first signal;

iii) means for storing the amplitude value of said second signal which corresponds to said original color;

iv) a transducer for applying pressure on said skin area, and for obtaining an amplitude of the second signal which corresponds to maximum whitening of said skin area.

85. Apparatus according to claim 84, further comprising a processor for processing data collected by said transducer and for measuring the filling time of blood vessels after releasing said pressure.

86. Apparatus according to claim 85, wherein said measuring the filling time of blood vessels after releasing said pressure is provided by analysing a rate of change of light intensity of said second wavelength with respect to elapsed time after releasing said pressure.

87. Apparatus according to claim 84, further comprising a suitable mechanism for automatically applying and releasing said pressure.

88. Apparatus according to claim 84, further comprising a first temperature sensor for sensing skin temperature of a second skin area close to said first mentioned skin area, wherein said second skin area is substantially unaffected by heat effects generated by said apparatus.

89. Apparatus according to claim 88, further comprising a second temperature sensor for sensing skin temperature of said first mentioned area, wherein said first mentioned skin area is substantially unaffected by heat effects generated by said apparatus.

90. Apparatus according to claim 77, wherein said second cardio-respiratory sensors is a blood oxygenation (BO) sensor module configured for monitoring blood oxygenation state, wherein operation of said BO sensor module is based on pulse oximetry techniques.

91. Apparatus according to claim 90, wherein said BO sensor module is adapted for measuring SpO2 and comprises at least one emitter for emitting red and infra red light, and at least one photodetector for receiving backscattered light from a target area of said patient at said anatomical part.

92. Apparatus according to claim 91, wherein said at least one photodetector is adapted for operating according to any one of a transmission method or a reflectance method, wherein in said transmission method, said at least one emitter and said at least one photodetector are in opposed relationship with respect to an extremity during operation of said apparatus, and wherein in said reflectance method, said at least one photodetector is adapted for operating according to a reflectance method, and wherein said at least one emitter and said at least one photodetector are in adjacent relationship.

93. Apparatus according to claim 77, wherein said second cardio-respiratory sensors is a peripheral perfusion (PU) sensor module configured for monitoring a peripheral perfusion parameter other than CRT.

94. Apparatus according to claim 93, wherein operation of said PU sensor module is based on any one of the following:

—

photoplethysmographic techniques, and wherein said PU sensor module comprises at least one emitter for emitting light in the visible or non visible spectrum, and at least one photodetector for receiving backscattered light from a target area of said patient;

vascular ultrasonography techniques, and wherein said PU sensor module comprises at least one transducer for generating suitable ultrasonic waves, and at least one transducer for receiving sound waves reflected from a target area of said patient;

Doppler flowmetry techniques, and wherein said PU sensor module comprises at least one optic fiber operatively connected to a laser for emitting light, and at least one optical fiber for receiving backscattered light from a target area of said patient;

suitable plethysmographic techniques.

95. Apparatus according to claim 77, wherein said second cardio-respiratory sensors is a blood pressure (BP) sensor module configured for monitoring at least one of blood pressure, pulse rate, systemic vascular resistance.

96. Apparatus according to claim 95, wherein operation of said BP sensor module is based on suitable Penaz techniques.

97. Apparatus according to claim 95, wherein said BP sensor module comprises a plethysmograph and a pressure cuff, wherein a pressure applied by the cuff is controllable using an output of plethysmograph such as to maintain the output from the plethysmograph substantially constant.

98. Apparatus according to claim 77, wherein said apparatus further comprises a body temperature sensor for measuring a body temperature of said patient at said same anatomical part.

99. Apparatus according to claim 78, wherein said second cardio-respiratory sensor module comprises a blood oxygenation (BO) sensor module configured for monitoring blood oxygenation state;

and wherein said third cardio-respiratory sensor module comprises a blood pressure (BP) sensor module configured for monitoring at least one of blood pressure, pulse rate, systemic vascular resistance

100. Apparatus according to claim 77, wherein said apparatus is adapted for accommodating a finger of said patient, said finger comprising said same anatomical part.

101. A system for providing data indicative of cardio-respiratory state of a patient comprising:

—

apparatus as defined in claim 77; and

user interface for enabling data relating to at least two said cardio-vascular parameters obtained from said apparatus to be at least one of processed and displayed.

102. A system according to claim 101, wherein said apparatus is operatively connected to said user interface via at least one of a suitable cable and a suitable wireless connection.

103. A system according to claim 102, wherein said wireless connection is via the Internet.

104. A system according to claim 101, wherein said apparatus is integrated with said user interface in the form of a handheld device.

105. A method for providing data indicative of cardio-respiratory state of a patient comprising measuring at least two cardio-respiratory parameters of said patient, wherein one said cardio-respiratory parameter is capillary refill time (CRT) and wherein another said cardio-respiratory parameter is any one of blood oxygenation state, a perfusion parameter (PU) other than capillary refill time (CRT), blood pressure, pulse rate, systemic vascular resistance, herein said at least two cardio-respiratory parameters are different one from the other and are measured at a same anatomical part of said patient.

106. A sheath for use with a sensing device, wherein the sheath is adapted to be worn over a finger, said sheath comprising at least one window for allowing communication between an inside and an outside of the sheath, wherein the sheath is adapted for becoming unusable as a sheath after being removed from a finger.

107. A sheath according to claim 106, wherein said sheath is made from a disposable material.

108. A sheath according to claim 106, wherein said sheath comprises an upper portion foldable over a lower portion in overlying relationship by means of a deformable first end portion therebetween, such as to define an opening at a second end thereof opposed to said first end, and an inner space for accommodating a finger.