Passive intraocular drug delivery devices and associated methods
First Claim
1. A device for passively delivering an active agent into an eye of a subject, comprising:
- a housing configured to conform to at least a portion of an eye surface;
a first reservoir component located within the housing and configured to be fluidically coupled to a first ocular surface, said first reservoir containing an ionized active agent;
a second reservoir component located within the housing and configured to be fluidically coupled to a second ocular surface located adjacent to the first ocular surface, said second reservoir component containing a depot forming agent having a charge that is opposite in polarity as compared to the ionized active agent;
wherein the ionized active agent and the depot forming agent are configured to form a precipitate when contacted together at room to body temperature and at a pH of between about 4 to about 8 in an aqueous medium; and
wherein the device does not include an electrode.
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Accused Products
Abstract
The present invention provides methods and devices for the passive delivery of active agents into the eye of a subject. In one aspect, for example, a device for passively delivering an active agent into an eye of a subject may include a housing configured to conform to at least a portion of an eye surface, and a first reservoir component located within the housing and configured to be fluidically coupled to a first ocular surface, where the first reservoir contains an ionized active agent. The device may further include a second reservoir component located within the housing and configured to be fluidically coupled to a second ocular surface located adjacent to the first ocular surface, where the second reservoir component contains a depot forming agent having a charge that is opposite in polarity as compared to the ionized active agent. The ionized active agent and the depot forming agent are configured to form a precipitate when contacted together at room to body temperature and at a pH of between about 4 to about 8 in an aqueous medium. Additionally, the device does not include an electrode.
26 Citations
25 Claims
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1. A device for passively delivering an active agent into an eye of a subject, comprising:
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a housing configured to conform to at least a portion of an eye surface; a first reservoir component located within the housing and configured to be fluidically coupled to a first ocular surface, said first reservoir containing an ionized active agent; a second reservoir component located within the housing and configured to be fluidically coupled to a second ocular surface located adjacent to the first ocular surface, said second reservoir component containing a depot forming agent having a charge that is opposite in polarity as compared to the ionized active agent; wherein the ionized active agent and the depot forming agent are configured to form a precipitate when contacted together at room to body temperature and at a pH of between about 4 to about 8 in an aqueous medium; and wherein the device does not include an electrode. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. A device for passively delivering an active agent into an eye of a subject, comprising:
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a housing configured to conform to at least a portion of an eye surface; a first reservoir component located within the housing and configured to be fluidically coupled to a first ocular surface, said first reservoir configured to contain an active agent and wherein the first reservoir component is not associated with an electrode; and a second reservoir component located within the housing and configured to be fluidically coupled to a second ocular surface located adjacent to the first ocular surface, said second reservoir configured to contain a depot forming agent and wherein the second reservoir component is not associated with an electrode.
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17. A system for passively delivering an active agent into an eye of a subject, comprising:
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a housing configured to conform to at least a portion of an eye surface, wherein the housing is not associated with an electrode; an active agent reservoir located within the housing and configured to be fluidically coupled to a first ocular surface, said active agent reservoir containing an ionized active agent; a depot forming agent having a charge that is opposite in polarity as compared to the ionized active agent; and wherein the ionized active agent and the depot forming agent are configured to form a precipitate when contacted together at room to body temperature and at a pH of between about 4 to about 8 in an aqueous medium. - View Dependent Claims (18)
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19. A method for forming an active agent depot within the eye of a subject, comprising:
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contacting a housing against an eye surface, the housing further including; a first reservoir component located within the housing and configured to be fluidically coupled to a first ocular surface, said first reservoir containing an ionized active agent; a second reservoir component located within the housing and configured to be fluidically coupled to a second ocular surface located adjacent to the first ocular surface, said second reservoir component containing a depot forming agent having a charge that is opposite in polarity as compared to the ionized active agent; wherein the ionized active agent and the depot forming agent are configured to form a precipitate when contacted together at room to body temperature and at a pH of between about 4 to about 8 in an aqueous medium; and delivering passively the ionized active agent from the first reservoir component into the eye at a first delivery location; delivering passively the depot forming agent from the second reservoir component into the eye at a second delivery location; and precipitating the ionized active agent and the depot forming agent into an active agent depot at a depot location within the eye that is dependent on the position of the first delivery location relative to the second delivery location. - View Dependent Claims (20, 21, 22)
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23. A method for forming an active agent depot within the eye of a subject, comprising:
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contacting a housing against an eye surface, the housing further including an active agent reservoir component located within the housing and configured to be fluidically coupled to a first ocular surface, said active agent reservoir containing an ionized active agent; contacting a depot forming agent with the eye, said depot forming agent having a charge that is opposite in polarity as compared to the ionized active agent, wherein the ionized active agent and the depot forming agent are configured to form a precipitate when contacted together at room to body temperature and at a pH of between about 4 to about 8 in an aqueous medium; and allowing sufficient time for the ionized active agent and the depot forming agent to passively diffuse into the eye and form an active agent depot. - View Dependent Claims (24, 25)
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Specification