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Passive intraocular drug delivery devices and associated methods

  • US 20090143752A1
  • Filed: 12/03/2007
  • Published: 06/04/2009
  • Est. Priority Date: 12/03/2007
  • Status: Abandoned Application
First Claim
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1. A device for passively delivering an active agent into an eye of a subject, comprising:

  • a housing configured to conform to at least a portion of an eye surface;

    a first reservoir component located within the housing and configured to be fluidically coupled to a first ocular surface, said first reservoir containing an ionized active agent;

    a second reservoir component located within the housing and configured to be fluidically coupled to a second ocular surface located adjacent to the first ocular surface, said second reservoir component containing a depot forming agent having a charge that is opposite in polarity as compared to the ionized active agent;

    wherein the ionized active agent and the depot forming agent are configured to form a precipitate when contacted together at room to body temperature and at a pH of between about 4 to about 8 in an aqueous medium; and

    wherein the device does not include an electrode.

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