Method and apparatus for delivering pacing pulses using a coronary stent

• US 20090143835A1
• Filed: 02/02/2009
• Published: 06/04/2009
• Est. Priority Date: 05/13/2005
• Status: Abandoned Application

• Current Assignee: Andrew P. Kramer, Frits W. Prinzen, Jeffrey Ross, Joseph M. Pastore, Julio C. Spinelli, Richard N. Cornelussen, Rodney W. Salo, Tamara Colette Baynham, Ward Y.R. Vanagt
• Original Assignee: Andrew P. Kramer, Frits W. Prinzen, Jeffrey Ross, Joseph M. Pastore, Julio C. Spinelli, Richard N. Cornelussen, Rodney W. Salo, Tamara Colette Baynham, Ward Y.R. Vanagt
• Inventors: Baynham, Tamara Colette, Spinelli, Julio C., Pastore, Joseph M., Kramer, Andrew P., Salo, Rodney W., Prinzen, Frits W., Vanagt, Ward Y. R., Cornelussen, Richard N., Ross, Jeffrey
• Application Number:
  US12/322,382
• Publication Number:
  US 20090143835A1
• Time in Patent Office: Days
• US Class Current: 607/17
• CPC Class Codes: A61N 1/056 Transvascular endocardial electrode systems
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/36557 controlled by chemical substances in blood
• CPC Class Codes: A61N 1/37205 Microstimulators, e.g. implantable through a cannula
• CPC Class Codes: A61N 1/3787 from an external energy source
• CPC Class Codes: A61N 2001/0585 Coronary sinus electrodes

Abstract

An implantable cardiac protection pacing system delivers pacing pulses to protect the heart from injuries associated with ischemia and myocardial infarction. The system includes an implantable pulse generator (PG) that delivers the pacing pulses and a coronary stent electrically connected to the implantable PG to function as a pacing electrode through which the pacing pulses are delivered. In one embodiment, an intravascular lead provides the electrical connection between the coronary stent and the implantable PG to allow the implantable PG to be implanted in the femoral region. In another embodiment, the coronary stent and the implantable PG are integrated into an intravascular pulse generator-stent.

Claims

1. A cardiac pacing system, comprising:

an implantable pulse generator including;

a pulse output circuit adapted to deliver pacing pulses; and

a control circuit coupled to the pulse output circuit and including a cardiac protection pacing timer adapted to time one or more cardiac protection pacing sequences each including alternating pacing and non-pacing periods, the pacing periods each having a pacing duration during which the delivery of the pacing pulses is controlled according to a programmed pacing mode, the non-pacing periods each having a non-pacing duration during which none of the pacing pulses is delivered;

a coronary stent including at least one electrode portion suitable for delivering the pacing pulses; and

an intravascular lead configured to be coupled between the implantable pulse generator and the coronary stent to provide for electrical connection between the at least one electrode portion and the pulse output circuit to allow the pacing pulses to be delivered to the at least one electrode portion.

2. The system of claim 1, wherein the intravascular lead has a diameter in a range of approximately 0.125 millimeters to 1 millimeter.

3. The system of claim 1, wherein the intravascular lead comprises at least a portion coated with an anti-coagulative agent.

4. The system of claim 1, wherein the cardiac protection pacing timer is adapted to initiate the one or more cardiac protection pacing sequences according to a predetermined schedule.

5. The system of claim 1, wherein the cardiac protection pacing timer is adapted to time a postconditioning sequence of the one or more cardiac protection pacing sequences during a postconditioning timing mode, switch the postconditioning timing mode to a preconditioning timing mode, and time a plurality of prophylactic preconditioning pacing sequences of the one or more cardiac protection pacing sequences during the preconditioning timing mode.

6. The system of claim 1, wherein the control circuit comprises a command receiver adapted to receive a pacing command, and the cardiac protection pacing timer is adapted to initiate at least one of the one or more cardiac protection pacing sequences in response to the pacing command.

7. The system of claim 6, wherein the control circuit comprises an event detector adapted to detect a predetermined type event and produce the pacing command in response to the detection of the predetermined type event.

8. The system of claim 7, wherein the event detector comprises an ischemia detector adapted to detect an ischemic event.

9. The system of claim 6, wherein the implantable pulse generator comprises an implant telemetry circuit coupled to the command receiver and adapted to receive the pacing command.

10. The system of claim 1, further comprising a strain sensor incorporated into the coronary stent and coupled to the control circuit, the strain sensor adapted to sense a signal indicative of bending forces applied onto the coronary stent.

11. A cardiac pacing system, comprising:

an implantable pulse generator configured for subcutaneous placement, the implantable pulse generator including;

a control circuit including a cardiac protection pacing timer adapted to time one or more cardiac protection pacing sequences each including alternating pacing and non-pacing periods, the pacing periods each having a pacing duration during which a plurality of pacing pulses is delivered, the non-pacing periods each having a non-pacing duration during which no pacing pulse is delivered; and

a pulse output circuit, coupled to the control circuit, to deliver the plurality of pacing pulses during each of the pacing periods;

a coronary stent including at least one electrode portion electrically connected to the pulse output circuit for delivering the plurality of pacing pulses during the each of the pacing periods; and

an intravascular lead providing for the electrical connection between the at least one electrode portion of the coronary stent and the pulse output circuit of the implantable pulse generator, the lead having a length in a range of approximately 30 centimeters to 120 centimeters and a diameter in a range of approximately 0.125 millimeters to 1 millimeter and including at least a portion coated with an anti-coagulative agent.

12. The system of claim 11, wherein the control circuit comprises a command receiver adapted to receive a pacing command, and the cardiac protection pacing timer is adapted to initiate at least one of the one or more cardiac protection pacing sequences in response to the pacing command.

13. The system of claim 12, wherein the control circuit comprises an ischemia detector adapted to detect an ischemic event and produce the pacing command in response to the detection of the ischemic event.

14. The system of claim 12, wherein the implantable pulse generator comprises an implant telemetry circuit coupled to the command receiver and adapted to receive the pacing command.

15. A method for operating a pacing system, comprising:

timing one or more cardiac protection pacing sequences each including alternating pacing and non-pacing periods, the pacing periods each having a pacing duration during which a plurality of pacing pulses is delivered from an implantable pulse generator, the non-pacing periods each having a non-pacing duration during which no pacing pulses is delivered from the implantable pulse generator; and

delivering the plurality of pacing pulses to a coronary stent through an intravascular lead during each of the pacing periods, the coronary stent including at least one electrode portion electrically coupled to the implantable pulse generator and functioning as a pacing electrode.

16. The method of claim 15, wherein delivering the plurality of pacing pulses comprises setting a pacing rate to approximately 20 pulses per minute higher than an intrinsic heart rate.

17. The method of claim 15, wherein timing the one or more cardiac protection pacing sequences comprises timing a postconditioning sequence of the one or more cardiac protection pacing sequences, the postconditioning sequence having a postconditioning sequence duration in a range of approximately 30 seconds to 1 hour and including alternating postconditioning pacing and non-pacing periods, the postconditioning pacing periods each having a postconditioning pacing duration in a range of approximately 5 seconds to 10 minutes during which the plurality of pacing pulses is delivered, the postconditioning non-pacing periods each having a postconditioning non-pacing duration in a range of approximately 5 seconds to 10 minutes during which no pacing pulse is delivered.

18. The method of claim 15, wherein timing the one or more cardiac protection pacing sequences comprises timing a plurality of prophylactic preconditioning pacing sequences of the one or more cardiac protection pacing sequences, the prophylactic preconditioning pacing sequences each having a preconditioning sequence duration in a range of approximately 10 minutes to 1 hour and including alternating preconditioning pacing and non-pacing periods, the preconditioning pacing periods each having a preconditioning pacing duration in a range of approximately 1 minute to 30 minutes during which the plurality of pacing pulses is delivered, the preconditioning non-pacing periods each having a preconditioning non-pacing duration in a range of approximately 1 minute to 30 minutes during which no pacing pulse is delivered.

19. The method of claim 18, wherein timing the plurality of prophylactic preconditioning pacing sequences comprises initiating the prophylactic preconditioning pacing sequences on a periodic basis using a predetermined period in a range of approximately 30 minutes to 72 hours.

20. The method of claim 15, wherein timing the one or more cardiac protection pacing sequences comprises timing a postconditioning sequence of the one or more cardiac protection pacing sequences during a postconditioning timing mode, switching the postconditioning timing mode to a preconditioning timing mode, and timing a plurality of prophylactic preconditioning pacing sequences of the one or more cardiac protection pacing sequences during the preconditioning timing mode.

21. The method of claim 15, wherein timing the one or more cardiac protection pacing sequences comprises:

receiving a pacing command; and

initiating at least one of the one or more cardiac protection pacing sequences in response to the pacing command.

22. The method of claim 21, further comprising:

detecting a predetermined type event; and

producing the pacing command in response to the detection of the predetermined type event.

23. The method of claim 22, wherein detecting the predetermined type event comprises detecting an ischemic event.

24. The method of claim 21, further comprising receiving the pacing command from a user.

25. The method of claim 15, wherein delivering the plurality of pacing pulses to the coronary stent through the intravascular lead comprises delivering the plurality of pacing pulses to the coronary stent through a lead extending from the coronary stent in a coronary artery through an aorta and a femoral artery to an opening on the femoral artery.