Baroreflex modulation to gradually decrease blood pressure
First Claim
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1. A method, comprising:
- sensing blood pressure using an implantable medical device; and
progressively lowering blood pressure from a start time to a target end time so that the sensed blood pressure reaches a target blood pressure upon reaching the target end time using a programmed algorithm in the implantable medical device, wherein the target end time and the target blood pressure are programmed into the implantable medical device,wherein progressively lowering the sensed blood pressure includes delivering neural stimulation that is effective in lowering blood pressure, and using the programmed algorithm to adjust an intensity of the neural stimulation to cause the blood pressure to be progressively lowered so that the sensed blood pressure reaches the target blood pressure near the target end time.
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Abstract
An aspect of the present subject matter relates to a baroreflex stimulator. An embodiment of the stimulator includes a pulse generator to provide a baroreflex stimulation signal through an electrode, and a modulator. The modulator modulates the baroreflex stimulation signal to increase the baroreflex stimulation therapy by a predetermined rate of change to lower systemic blood pressure to a target pressure. Other aspects are provided herein.
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Citations
20 Claims
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1. A method, comprising:
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sensing blood pressure using an implantable medical device; and progressively lowering blood pressure from a start time to a target end time so that the sensed blood pressure reaches a target blood pressure upon reaching the target end time using a programmed algorithm in the implantable medical device, wherein the target end time and the target blood pressure are programmed into the implantable medical device, wherein progressively lowering the sensed blood pressure includes delivering neural stimulation that is effective in lowering blood pressure, and using the programmed algorithm to adjust an intensity of the neural stimulation to cause the blood pressure to be progressively lowered so that the sensed blood pressure reaches the target blood pressure near the target end time. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A method, comprising:
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sensing blood pressure; determining cardiac output; and implementing a programmed algorithm in an implantable medical device to control an intensity of neural stimulation delivered by the implantable medical device to gradually lower blood pressure with time from a start time to an end time to reach a programmed target blood pressure near the end time, wherein the programmed algorithm adjusts the intensity of the neural stimulation as a function of the sensed blood pressure, the programmed target blood pressure, time remaining until reaching the end time, and the cardiac output. - View Dependent Claims (12, 13, 14)
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15. A method for operating an implantable medical device, comprising:
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receiving an event trigger to initiate a neural stimulation process performed by the implantable medical device to gradually lower blood pressure; implementing an algorithm programmed into the implantable medical device to control an intensity of the neural stimulation to gradually lower blood pressure to a target pressure programmed into the implantable medical device, wherein implementing the algorithm to control the intensity of the neural stimulation to gradually lower blood pressure includes initially delivering neural stimulation to slightly lower blood pressure, and then gradually increasing the intensity of the neural stimulation to gradually lower the blood pressure further to the target pressure; interrupting the algorithm when the neural stimulation reaches the target pressure; and determining if cardiac output is acceptable and if cardiac output is not acceptable, modifying the algorithm to modify how the blood pressure is gradually lowered. - View Dependent Claims (16, 17, 18, 19, 20)
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Specification