METHODS AND APPARATUSES FOR GENERATING A SEAL BETWEEN A CONDUIT AND A RESERVOIR WELL

• US 20090146380A1
• Filed: 08/10/2006
• Published: 06/11/2009
• Est. Priority Date: 08/11/2005
• Status: Abandoned Application

• Current Assignee: AB Sciex LLC (Danaher Corporation)
• Original Assignee: Eksigent Technologies LLC
• Inventors: Junge, Kelly, Crenshaw, Hugh C., Pollack, Michael G., Votaw, Gregory A.
• Application Number:
  US11/719,522
• Publication Number:
  US 20090146380A1
• Time in Patent Office: Days
• US Class Current: 277/314
• CPC Class Codes: B01F 25/314 wherein additional components are introduced at the circumference of the conduit
• CPC Class Codes: B01F 25/433 Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
• CPC Class Codes: B01F 25/4336 Mixers with a diverging cross-section
• CPC Class Codes: B01F 33/30 Micromixers
• CPC Class Codes: B01L 2300/044 pierceable, e.g. films, membranes
• CPC Class Codes: B01L 2300/0816 Cards, e.g. flat sample carriers usually with flow in two horizontal directions
• CPC Class Codes: B01L 2300/1822 using Peltier elements
• CPC Class Codes: B01L 2300/1883 using thermal insulation
• CPC Class Codes: B01L 2300/1894 Cooling means; Cryo cooling
• CPC Class Codes: B01L 2400/0487 fluid pressure, pneumatics
• CPC Class Codes: B01L 2400/0677 phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers
• CPC Class Codes: B01L 3/502707 characterised by the manufacture of the container or its components by shaping or joining plastic parts B29C59/00, B29C65/00; by laminating B32B37/00; manufacture of microstructural devices in general B81C
• CPC Class Codes: B01L 3/502715 characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
• CPC Class Codes: B01L 3/50273 characterised by the means or forces applied to move the fluids micropumps F04B19/006, of the membrane type F04B43/043
• CPC Class Codes: B01L 3/502738 characterised by integrated valves microvalves F16K99/0001
• CPC Class Codes: B01L 3/565 Seals in general F16L
• CPC Class Codes: F04B 19/006 Micropumps F04B43/043 and F04B43/095 take precedence

Abstract

Methods and Apparatuses for Generating a Seal Between a Conduit and a Reservoir Well. According to one embodiment, an apparatus is provided for generating a seal between a conduit and a reservoir well. The apparatus can include a mount including a first and second end. The mount can also include a first aperture extending between the first and second ends. The apparatus can also include a tube including a first end engaging the first end of the mount, and operable to hold a conduit having an end such that the conduit extends through the first aperture of the mount and the end of the conduit communicates with a reservoir well. Further, the apparatus can include a nut operable to engage the mount and tube and seal the conduit to the first aperture of the mount such that air cannot communicate from the reservoir well through the first aperture of the mount.

Claims

1. An apparatus for generating a seal between a conduit and a reservoir well, comprising:

(a) a mount including a first and second end, and including a first aperture extending between the first and second ends;

(b) a tube including a first end engaging the first end of the mount, and operable to hold a conduit having an end such that the conduit extends through the first aperture of the mount and the end of the conduit communicates with a reservoir well; and

(c) a nut operable to engage the mount and tube and seal the conduit to the first aperture of the mount such that air cannot communicate from the reservoir well through the first aperture of the mount.

2. The apparatus according to claim 1 wherein the first end of the mount comprises a threadable interior for engaging the nut.

3. The apparatus according to claim 2 wherein the nut includes a threadable exterior for engaging the threadable interior of the first end of the mount.

4. The apparatus according to claim 1 wherein the conduit comprises a fused silica capillary.

5. The apparatus according to claim 1 wherein the reservoir well comprises a covering, and comprising a needle attached to the mount and operable to penetrate the covering of the reservoir well and hold the end of the conduit in the reservoir well.

6. The apparatus according to claim 5 wherein the tube is a first tube, and comprising a rigid tube including a first end and second end, the first end of the rigid tube engaging the second end of the mount, the second end of the rigid tube extending into the needle, and operable to hold the conduit.

7. The apparatus according to claim 6 comprising a spring mechanism operable to provide resistance to movement of the mount with respect to the rigid tube and the first tube.

8. The apparatus according to claim 5 comprising an air pressure manifold communicating with the needle for communicating air from an air supply into the reservoir well such that fluid in the reservoir well is forced into the end of the conduit.

9. The apparatus according to claim 8 wherein the rigid tube extends through the air pressure manifold.

10. The apparatus according to claim 9 comprising an air-lock nut operable to engage the rigid tube and the air pressure manifold for forming a seal therebetween.

11. The apparatus of claim 1 comprising an o-ring operable to engage the mount and the needle for forming a seal therebetween.

12. The apparatus according to claim 1 wherein the reservoir well comprises an opening, and comprising:

(a) a needle attached to the mount and operable to hold the end of the conduit in the reservoir well; and

(b) a gasket including an aperture operable to hold the needle in the reservoir well and sealingly engage the opening of the reservoir well.

13. The apparatus according to claim 1 comprising:

(a) a needle attached to the mount and operable to hold the end of the conduit in the reservoir well;

(b) a gasket including an aperture operable to sealingly engage an opening of the reservoir well and position the needle in the reservoir well; and

(c) a spring including a first and second end, the first end of the spring attached to the needle, and the second end of the spring attached to the gasket such that the gasket is evenly applied to the opening of the reservoir well when the needle is positioned in the reservoir well.

14. A method for generating a seal between a conduit and a reservoir well, the method comprising:

(a) providing a mount including a first and second end, and including a first aperture extending between the first and second ends;

(b) providing a tube including a first end engaging the first end of the mount, and operable to hold a conduit having an end such that the conduit extends through the first aperture of the mount and the end of the conduit communicates with a reservoir well;

(c) providing a nut operable to engage the mount and tube and seal the conduit to the first aperture of the mount such that air cannot communicate from the reservoir well through the first aperture of the mount; and

(d) inserting the conduit into the tube such that the end of the tube is positioned in the reservoir well.

15. The method according to claim 14 wherein the first end of the mount comprises a threadable interior for engaging the nut.

16. The method according to claim 14 wherein the nut includes a threadable exterior for engaging the threadable interior of the first end of the mount.

17. The method according to claim 14 wherein the conduit comprises a fused silica capillary.

18. The method according to claim 14 wherein the reservoir well comprises a covering, and comprising:

(a) providing a needle attached to the mount and operable to hold the end of the conduit; and

(b) inserting the needle into the covering of the reservoir well such that the end of the conduit is in the reservoir well.

19. The method according to claim 18 comprising providing a rigid tube including a first end and second end, the first end of the rigid tube engaging the second end of the mount, the second end of the rigid tube extending into the needle, and operable to hold the conduit.

20. The method according to claim 19 comprising providing an air pressure manifold communicating with the needle for communicating air from an air supply into the reservoir well such that fluid in the reservoir well is forced into the end of the conduit.

21. The method according to claim 20 wherein the rigid tube extends through the air pressure manifold.

22. The method according to claim 21 comprising providing an air-lock nut operable to engage the rigid tube and the air pressure manifold for forming a seal therebetween.

23. The method according to claim 14 wherein the reservoir well comprises and opening, and comprising:

(a) providing a needle attached to the mount and operable to hold the end of the conduit in the reservoir well; and

(b) providing a gasket including an aperture operable to hold the needle in the reservoir well and sealingly engage the opening of the reservoir well.

24-39. -39. (canceled)

40. An apparatus for generating a seal between a conduit and a reservoir well, comprising:

(a) a reservoir well comprising a covering;

(b) a mount including a first and second end, and including an aperture extending between the first and second ends;

(c) a conduit having an end such that the conduit extends through the first aperture of the mount, the end of the conduit communicates with the reservoir well;

(d) a nut and tube operable to seal the conduit to the first aperture of the mount such that air cannot communicate from the reservoir well through the first aperture of the mount, and operable to permit the conduit to move with respect to the first aperture; and

(e) a needle operable to penetrate the covering of the reservoir well, and hold an end of the tube in the reservoir well.

41-53. -53. (canceled)