IN-SITU DATA COLLECTION ARCHITECTURE FOR COMPUTER-AIDED DIAGNOSIS

• US 20090148011A1
• Filed: 11/16/2005
• Published: 06/11/2009
• Est. Priority Date: 11/19/2004
• Status: Abandoned Application

• Current Assignee: Koninklijke Philips Electronics N.V. (Koninklijke Philips N.V.)
• Original Assignee: Koninklijke Philips Electronics N.V. (Koninklijke Philips N.V.)
• Inventors: Zhao, Luyin
• Application Number:
  US11/719,793
• Publication Number:
  US 20090148011A1
• Time in Patent Office: Days
• US Class Current: 382/128
• CPC Class Codes: G16H 30/20 for handling medical images, e.g. DICOM, HL7 or PACS
• CPC Class Codes: G16H 50/20 for computer-aided diagnosis, e.g. based on medical expert systems

Abstract

Automated diagnostic decision support (104) in the imaging of potentially malignant lesions is distributed and streamlined to protect patient confidentiality and to lower bandwidth and transaction costs. At a client hospital site (108a, 108b), a software agent (132) monitors a database and responsively accesses an image of a lesion and ground truth that the lesion is malignant/benign (S310-S330). After computing at least one feature of the lesion based on the image (S340, S350), the software agent transmits the feature(s) and ground truth externally from the hospital, to a central diagnostic decision support server (S360, S370). When a client hospital site needs automatic diagnostic support, the lesion feature(s) of the new patient are likewise extracted and transmitted to the external server in a query message (S440). The classifier located on the server will return a diagnosis (benign/malignant) and a confidence level (S450, S460).

Claims

1. A method for collecting medical data, comprising the following acts:

(a) capturing, at a client site, an image of a lesion of a medical subject at the client site (S220);

(b) deriving, from the captured image, at least one feature of the lesion (S350); and

(c) transmitting, by the client site to a server disposed externally to the client site, one or more features derived in act (b) and ground truth that the lesion is either malignant or benign (S360, S370).

2. The method of claim 1, further comprising pairing the ground truth to said one or more features to form, optionally in combination with any other pairing of ground truth to one or more associated features according to the method of claim 1, the payload of a message to be transmitted in the transmitting (S360, S370).

3. The method of claim 2, wherein said server is common to a plurality of client sites each respectively performing the capturing and transmitting of claim 1 (108a, 108b).

4. The method of claim 3, further comprising:

receiving, by the server from a client site of the plural client sites, the transmitted payload (S420);

training, on the server, based on the received payload (S430);

sending, by the server to a destination client site of the plural client sites, diagnostic decision support information (S460);

receiving, by the destination client site, the sent diagnostic decision support information (120); and

presenting, at said destination client site, the received diagnostic decision support information (120).

5. The method of claim 1, wherein said deriving is performed at the client site (132), said method further comprising deriving, at the client site, said ground truth (S260).

6. The method of claim 1, comprising:

making a diagnosis that the lesion is either malignant or benign (S240); and

confirming, by pathology, the diagnosis as either valid or invalid, thereby creating said ground truth (S250).

7. The method of claim 1, further including the act of excluding, from the transmitting, any information identifying said medical subject (S330).

8. A data collecting device (116) located at a client site and configured for:

receiving ground truth that a lesion of a medical subject is either malignant or benign (S260);

pairing the received ground truth with at least one feature characteristic of the lesion computed from an image of the lesion (S350, S360); and

transmitting the pair to a server disposed externally to the client site (S370).

9. The device of claim 8, further comprising:

a user interface by which to input the ground truth (120); and

the same or different user interface (120), said device being configured for receiving, from said server, over said same or different user interface diagnostic decision support information (S460).

10. The device of claim 8, wherein said pairing forms, optionally in combination with any other pairing of ground truth to one or more associated features according to the method of claim 8, the payload of a message sent in said transmitting (S450, S460).

11. The device of claim 8, further comprising a database for saving a location of said lesion in the image and the respective ground truth for the lesion (124).

12. The device of claim 11, further comprising:

a memory (128); and

in the memory, a software agent configured for, optionally subject to authorization (164), accessing the database to compute said at least one feature and to retrieve said respective ground truth (132).

13. The device of claim 12, wherein said agent includes:

a segmentation algorithm for segmenting the lesion in the image (140); and

a feature extraction algorithm for computing said at least one feature by extracting, from the segmented lesion in said image, said at least one feature (136).

14. The device of claim 8, configured for excluding, from the transmitting, any information identifying said medical subject (S330).

15. The device of claim 8, further configured for computing said at least one feature, said at least one feature comprising a measure of at least one of:

circularity, mean gray value, angularity, margin, shape, density and speculation (S350).

16. An apparatus located at the client site and comprising:

the device of claim 8 (116); and

an imaging device configured for capturing said image from the medical subject at the client site (112).

17. A system for collecting medical data, comprising:

said server of claim 8 (104); and

a plurality of the devices of claim 8 located at respective client sites that are each clients of said server (108a, 108b).

18. The system of claim 17, wherein at least one of the plural devices is further configured for:

in performing the pairing, forming, into a message payload, the ground truth to be transmitted and the at least one feature to be transmitted; and

in performing said transmitting, sending the message payload (S360, S370).

19. A server (104) comprising:

a receiver for receiving, from any of the plural client sites, a respective pair comprising (a) ground truth that a lesion is either malignant or benign; and

(b) at least one feature of a lesion derived from an image of the lesion (144); and

a diagnostic support processor for incrementally training (S430), based on the received pair, said sites being located externally from each other and from the server (148).

20. The server of claim 19, further comprising a transmitter for sending, to a destination client site of the plural client sites, diagnostic decision support information (152).

21. The server of claim 19, wherein said respective pair forms, optionally in combination with any other pairing of ground truth to one or more associated features according to claim 19, the payload of a message transmitted from one of the plural client sites, such that the receiving of the respective pair or pairs receives the message payload (S360, S370).

22. A computer software product for collecting medical data (132), said product being located at a client site and embedded within a medium (128) readable by a processor, said product comprising instructions executable to perform acts comprising:

monitoring a database at the client site (S310);

responsive to said monitoring, accessing, from the database, an image of a lesion of a medical subject and ground truth that the lesion is either malignant or benign (S320, S330); and

outputting, for transmission to a server disposed externally to the client site, the accessed ground truth and at least one feature of the lesion derived from the accessed image (S360, S370).

23. The product of claim 22, comprising instructions executable to perform the act of pairing:

(a) the ground truth to be transmitted; and

(b) said at least one feature to be transmitted, the pair forming, optionally in combination with any other pairing of ground truth to one or more associated features according to claim 22, the payload of a message to be transmitted in said transmission (S360, S370).