OPTICAL DETERMINATION OF GLUCOSE UTILIZING BORONIC ACID ADDUCTS
First Claim
1. A device for optically determining an analyte concentration, which device comprises:
- an analyte permeable component;
a fluorophore associated with the analyte permeable component and configured to absorb light at a first wavelength and emit light at a second wavelength, wherein the fluorophore comprises a substituted pyrene sulfonate;
a quencher associated with the analyte permeable component and configured to modify the light emitted by the fluorophore by an amount related to the analyte concentration;
a light source; and
a detector.
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Abstract
The present invention concerns an improved optical method and optical sensing device for determining the levels of polyhydroxyl-substituted organic molecules in vitro and/or in vivo in aqueous media. The range of detection is between about 400 and 800 nm. In particular, a sensory devise is implemented in a mammal to determine sugar levels. Specifically, a dye is combined with a conjugated nitrogen-containing heterocyclic aromatic boronic acid-substituted bis-onium compound in the presence of a sugar, such as fructose or glucose. The viologens are preferred as the aromatic conjugated nitrogen-containing boronic acid substituted compounds. The method is useful to determine sugar levels in a human being.
4 Citations
20 Claims
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1. A device for optically determining an analyte concentration, which device comprises:
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an analyte permeable component; a fluorophore associated with the analyte permeable component and configured to absorb light at a first wavelength and emit light at a second wavelength, wherein the fluorophore comprises a substituted pyrene sulfonate; a quencher associated with the analyte permeable component and configured to modify the light emitted by the fluorophore by an amount related to the analyte concentration; a light source; and a detector. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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Specification