METHODS AND DEVICES FOR ENHANCED BIOCOMPATIBILITY
First Claim
1. A method for increasing the biocompatibility between an implantable device and a biological matter, comprising:
- functionalizing said device by attaching at least one unique molecule to at least a portion of at least one surface of the device;
wherein said at least one unique molecule specifically binds to a binding site of at least one tissue component of said biological matter.
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Abstract
The present invention is directed to devices with enhanced biocompatibility and methods for generating and utilizing such devices. The present invention is further directed to enhanced biocompatibility utilizing oligonucleotide functionalization. In one aspect, a device for implantation and/or prolonged exposure to the body tissues includes a functionalized surface. The functionalized surface generally enhances the biocompatibility of the device with body tissues. In some embodiments, the functionalized surface includes substances for controlling interaction between the device and the body tissues. Substances for controlling interactions may include, but are not limited to, polymeric materials, biomolecules, ions and/or ion-releasing substances, and/or any other appropriate substance or combination thereof. In exemplary embodiments, the functionalized surface includes oligonucleotides for controlling interaction between the device and the body tissues. In some exemplary embodiments, the oligonucleotides are aptamers.
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Citations
24 Claims
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1. A method for increasing the biocompatibility between an implantable device and a biological matter, comprising:
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functionalizing said device by attaching at least one unique molecule to at least a portion of at least one surface of the device; wherein said at least one unique molecule specifically binds to a binding site of at least one tissue component of said biological matter. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A method for increasing the biocompatibility of a device, comprising:
attaching at least one unique molecule to at least a portion of a surface of the device in a spatial distribution for increasing the probability of binding to at least one target in a body tissue, wherein said unique molecule comprises an aptamer. - View Dependent Claims (15, 16, 17, 18, 19)
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20. An implantable device with improved biocompatibility with biological matter, comprising:
at least one portion of at least one surface functionalized with at least one unique molecule for binding to various components of a biological tissue, wherein said unique molecule comprises an oligonucleotide. - View Dependent Claims (21, 22, 23, 24)
Specification