SURFACE ENGINEERING OF TISSUE GRAFT MATERIALS FOR ENHANCED POROSITY AND CELL ADHESION

• US 20090149569A1
• Filed: 07/21/2008
• Published: 06/11/2009
• Est. Priority Date: 07/19/2007
• Status: Abandoned Application

• Current Assignee: Vanderbilt University
• Original Assignee: Vanderbilt University
• Inventors: Oliveira, Henrique Franca Diniz, Shastri, V. Prasad
• Application Number:
  US12/176,765
• Publication Number:
  US 20090149569A1
• Time in Patent Office: Days
• US Class Current: 523/113
• CPC Class Codes: A61L 27/446 with other specific inorganic fillers other than those covered by A61L27/443 or A61L27/46
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61P 19/08 for bone diseases, e.g. rachitism, Paget's disease
• CPC Class Codes: C08L 33/10 Homopolymers or copolymers of methacrylic acid esters

Abstract

In one aspect, the invention relates to providing enhanced application tissue graft materials in regenerative medicine through improved cellular interactions. Biocompatible implant materials, methods for preparing biocompatible implant materials, methods for using same, and methods for treating tissue injury are disclosed. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Claims

1. A biocompatible implant material comprising:

a. a polymeric tissue graft material having a surface and

b. a plurality of nonpolymeric porous particles disposed at the surface.

2. The implant material of claim 1, wherein the polymeric tissue graft material comprises a macroporous material.

3. The implant material of claim 1, wherein the polymeric tissue graft material comprises poly(hydroxyethyl methacrylate) and/or poly(methyl methacrylate).

4. The implant material of claim 1, wherein the nonpolymeric porous particles have an average particle size of from about 50 μ

m to about 500 μ

m, from about 100 μ

m to about 400 μ

m, from about 200 μ

m to about 300 μ

m, or from about 180 μ

m to about 250 μ

m.

5. The implant material of claim 1, wherein the nonpolymeric porous particles comprise a nonmetallic inorganic material.

6. The implant material of claim 1, wherein the nonpolymeric porous particles comprise coral.

7. The implant material of claim 1, wherein the polymeric tissue graft material comprises a microsphere comprising a poly(hydroxyethyl methacrylate) outer layer and a poly(methyl methacrylate) inner layer and wherein the nonpolymeric porous particles comprise coral particles.

8. A method for preparing a biocompatible implant material, the method comprising the steps of:

a. contacting a polymeric tissue graft material with an organic solvent and

b. mixing the microsphere with a plurality of nonpolymeric porous particles.

9. The method of claim 8, wherein the organic solvent comprises dichloromethane/ethanol.

10. The method of claim 8, wherein the polymeric tissue graft material comprises a macroporous material.

11. The method of claim 8, wherein the polymeric tissue graft material comprises poly(hydroxyethyl methacrylate) and/or poly(methyl methacrylate).

12. The method of claim 8, wherein the nonpolymeric porous particles comprise a nonmetallic inorganic material.

13. The method of claim 8, wherein the nonpolymeric porous particles comprise coral.

14. The method of claim 8, wherein the polymeric tissue graft material comprises a microsphere comprising a poly(hydroxyethyl methacrylate) outer layer and a poly(methyl methacrylate) inner layer and wherein the nonpolymeric porous particles comprise coral particles.

15. A method comprising administering to a subject a polymeric tissue graft material having a surface wherein a plurality of nonpolymeric porous particles are disposed at the surface.

16. The method of claim 15, wherein the polymeric tissue graft material is implanted in or adjacent to a bone or joint of the subject.

17. The method of claim 15, wherein the subject has a bone injury.

18. The method of claim 15, wherein the particles are disposed at said surface under conditions suitable to promote cell growth.

19. The method of claim 18, wherein the cells are stem cells or progenitor cells.

20. The method of claim 19, wherein the cells are osteoblasts.