SYNTHETIC RECEPTOR

• US 20090149607A1
• Filed: 04/28/2006
• Published: 06/11/2009
• Est. Priority Date: 05/06/2005
• Status: Abandoned Application

• Current Assignee: Cranfield University, Sphere Medical Limited (Sphere Medical Holding Ltd.)
• Original Assignee: Cranfield University, Sphere Medical Limited (Sphere Medical Holding Ltd.)
• Inventors: Piletsky, Sergey Anatoliyovich, Karim, Khalku, Laitenberger, Peter Georg, Hendry, Stuart P.
• Application Number:
  US11/913,497
• Publication Number:
  US 20090149607A1
• Time in Patent Office: Days
• US Class Current: 525/302
• CPC Class Codes: B01J 20/26 Synthetic macromolecular compounds
• CPC Class Codes: B01J 20/267 Cross-linked polymers
• CPC Class Codes: B01J 20/268 Polymers created by use of a template, e.g. molecularly imprinted polymers
• CPC Class Codes: C08F 220/06 Acrylic acid; Methacrylic acid; Metal salts or ammonium salts thereof
• CPC Class Codes: C08F 220/24 containing perhaloalkyl radicals
• CPC Class Codes: C08F 220/34 Esters containing nitrogen , e.g. N,N-dimethylaminoethyl (meth)acrylate
• CPC Class Codes: C08F 220/56 Acrylamide; Methacrylamide
• CPC Class Codes: C08F 222/02 Acids; Metal salts or ammonium salts thereof , e.g. maleic acid or itaconic acid
• CPC Class Codes: C08F 222/06 Maleic anhydride
• CPC Class Codes: C08F 222/102 of dialcohols, e.g. ethylene glycol di(meth)acrylate or 1,4-butanediol dimethacrylate
• CPC Class Codes: G01N 33/54373 involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
• CPC Class Codes: G01N 33/948 Sedatives, e.g. cannabinoids, barbiturates opiates G01N33/9486

Abstract

A polymer capable of selectively binding propofol is prepared from one or more suitable monomers (e.g. N,N-diethylaminoethyl methacrylate) and a cross-linker. It may be a molecularly imprinted polymer. An element (7) of the polymer may be used in a propofol sensor (1) mounted in a confinement structure (3) on a substrate (2).

Claims

1. A sensor comprising a polymer for binding propofol composed of a monomer selected from at least one or more of N,N-diethylamino ethyl methacrylate (DEAEM), acrylamide, 2-(trifluoromethyl)acrylic acid (TFMAA), itaconic acid and ethylene glycol methacrylate phosphate (EGMP), and a cross-linker.

2. A sensor as claimed in claim 1, wherein the cross-linker is selected from ethylene glycol dimethacrylate (EDMA), glycerol dimethacrylate (GDMA), trimethylacrylate (TRIM), divinylbenzene (DVB), methylenebisacrylamide and piperazinebisacrylamide (which are particularly suitable for cross linking acylamides), phenylene diamine, dibromobutane, epichlorohydrine, trimethylolpropane trimethacrylate and N,N′

-methylenebisacrylamide.

3. A sensor as claimed in claim 1, wherein the mole ratio of monomer to cross-linker is from 1:

1 to 1;

15.

4. A sensor as claimed in claim 1, wherein the polymer is a molecularly imprinted polymer capable of binding propofol.

5. A sensor as claimed in claim 4, wherein the polymer is a molecularly imprinted polymer imprinted with propofol.

6. A sensor as claimed in claim 1, wherein the sensor further comprises a substrate, and a confinement structure disposed on the substrate, wherein the confinement structure comprises at least a first limiting structure defining a first interior space for containing the polymer;

and a transducer proximal to the first interior space.

7. A method of binding propofol comprising contacting a solution containing it with a polymer composed of a monomer selected from N,N-diethylamino ethyl methacrylate (DEAEM), acrylamide, 2-(trifluoromethyl)acrylic acid (TFMAA), itaconic acid, ethylene glycol methacrylate phosphate (EGMP), and mixtures thereof, and a cross-linker for binding propofol.

8. A method as claimed in claim 7, wherein the cross-linker is selected from ethylene glycol dimethacrylate (EDMA), glycerol dimethacrylate (GDMA), trimethylacrylate (TRIM), divinylbenzene (DVB), methylenebisacrylamide and piperazinebisacrylamide (which are particularly suitable for cross linking acylamides), phenylene diamine, dibromobutane, epichlorohydrine, trimethylolpropane trimethacrylate and N,N′

-methylenebisacrylamide.

9. A method as claimed in claim 7, wherein the mole ratio of monomer to cross-linker is from 1:

1 to 1;

15.

10. A method as claimed in claim 7, wherein the polymer is a molecularly imprinted polymer imprinted with propofol.

11. A molecularly imprinted polymer imprinted with propofol composed of a monomer selected from N,N-diethylamino ethyl methacrylate (DEAEM), acrylamide, 2-(trifluoromethyl)acrylic acid (TFMAA), itaconic acid, ethylene glycol methacrylate phosphate (EGMP), and mixtures thereof, and a cross-linker.

12. A molecularly imprinted polymer as claimed in claim 11, wherein the cross-linker is selected from ethylene glycol dimethacrylate (EDMA), glycerol dimethacrylate (GDMA), trimethylacrylate (TRIM), divinylbenzene (DVB), methylenebisacrylamide and piperazinebisacrylamide (which are particularly suitable for cross linking acylamides), phenylene diamine, dibromobutane, epichlorohydrine, trimethylolpropane trimethacrylate and N,N′

-methylenebisacrylamide.

13. A molecularly imprinted polymer as claimed in claim 11, wherein the mole ratio of monomer to cross-linker is from 1:

1 to 1;

15.