SYSTEMS AND METHODS FOR DETERMINING INTRACRANIAL PRESSURE NON-INVASIVELY AND ACOUSTIC TRANSDUCER ASSEMBLIES FOR USE IN SUCH SYSTEMS
First Claim
1. A system for determining the ICP of a subject based on at least two variable inputs, comprising:
- a data acquisition component mountable to a subject'"'"'s body surface and having at least one acoustic source element and at least one acoustic detector element; and
a controller component comprising a signal generator providing acoustic interrogation signals to the at least one acoustic source element and a data processing component receiving a first variable input comprising acoustic data signals from the at least one acoustic detector element and receiving a second variable input selected from the group consisting of;
ABP, CNS tissue stiffness, CNS tissue displacement, partial pressure of at least one or more gases associated with CNS respiration and metabolism, pCO2, blood perfusion, hematocrit, and electrophysiological properties, the data processing component being programmed to determine ICP based on the first and second variable inputs.
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Accused Products
Abstract
Systems and methods for determining ICP based on parameters that can be measured using non-invasive or minimally invasive techniques are provided. Systems for acquiring acoustic data from a desired target site in a subject'"'"'s body using various types of acoustic source and detector elements are also provided, including single use acoustic source/detector combinations are also provided. Acoustic arrays for use with these systems may include multiple capacitive micro-machined ultrasound transducer (cMUT) elements, and may include a combination of different types of acoustic arrays. Methods of targeting localized sites within a broad target area based on acoustic data having various properties are also disclosed.
108 Citations
29 Claims
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1. A system for determining the ICP of a subject based on at least two variable inputs, comprising:
- a data acquisition component mountable to a subject'"'"'s body surface and having at least one acoustic source element and at least one acoustic detector element; and
a controller component comprising a signal generator providing acoustic interrogation signals to the at least one acoustic source element and a data processing component receiving a first variable input comprising acoustic data signals from the at least one acoustic detector element and receiving a second variable input selected from the group consisting of;
ABP, CNS tissue stiffness, CNS tissue displacement, partial pressure of at least one or more gases associated with CNS respiration and metabolism, pCO2, blood perfusion, hematocrit, and electrophysiological properties, the data processing component being programmed to determine ICP based on the first and second variable inputs. - View Dependent Claims (2, 3, 4, 5)
- a data acquisition component mountable to a subject'"'"'s body surface and having at least one acoustic source element and at least one acoustic detector element; and
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6. A system for acquiring acoustic data from a desired target site within a subject'"'"'s body, comprising:
- a data acquisition component mountable to a subject'"'"'s body surface and having at least one acoustic source element and at least one acoustic detector element, at least one of the source and detector element(s) comprising an acoustic transducer array composed of multiple cMUT acoustic transducer cells arranged in a (single) thin layer; and
a controller component in operable communication with the data acquisition component, the controller component comprising a signal generator providing energy for acoustic interrogation signals to the at least one acoustic source element and a data processing component receiving acoustic data signals from the at least one acoustic detector element. - View Dependent Claims (7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
- a data acquisition component mountable to a subject'"'"'s body surface and having at least one acoustic source element and at least one acoustic detector element, at least one of the source and detector element(s) comprising an acoustic transducer array composed of multiple cMUT acoustic transducer cells arranged in a (single) thin layer; and
- 17. A single use acoustic source/detector combination mountable to a subject'"'"'s body surface and having at least one acoustic source element and at least one acoustic detector element, at least one of the source and detector element(s) comprising an acoustic array composed of multiple acoustic transducers, the source/detector combination additionally comprising an acoustically transmissive material arranged to provide high fidelity acoustic transmission between the source and detector element(s) and the subject'"'"'s body surface during operation.
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23. A system for acquiring acoustic scatter data from a desired target site within a subject'"'"'s body, comprising:
- two acoustic arrays, each composed of at least one transducer elements, the two arrays being aligned generally orthogonal to one another, with one array capable of sweeping in a first orientation in send and receive modes and a second array being capable of sweeping in a direction generally orthogonal to the first orientation in receive and send modes.
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24. A system for acquiring acoustic data from a desired target site within a subject'"'"'s body, comprising:
- an acoustic source/detector combination including a PVDF transducer array serving as an acoustic detector and an acoustic source transducer or array transmitting through the PVDF array.
- View Dependent Claims (25)
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26. A system for acquiring acoustic data from a desired target site within a subject'"'"'s body, comprising:
- an acoustic source/detector combination including an acoustic source transducer comprising a PZT transducer, and a transducer array serving as an acoustic detector, wherein the PZT acoustic source transducer transmits through the acoustic detector array.
- View Dependent Claims (27)
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28. A method for targeting a localized target site within a broad target area, comprising acquiring acoustic data from multiple points within the broad target area, selecting at least one localized target site within the broad target area based on acoustic data selected from the group consisting of acoustic scatter data, phase or frequency of acoustic scatter data, changes in the primary and/or other maxima and/or minima amplitude, phase or frequency of acoustic signals within a cardiac and/or respiratory cycle;
- tissue stiffness properties, endogenous and/or induced tissue displacement properties, acoustic emissions associated with such displacements and rates of change of such properties acquired from the multiple points within the broad target area, and focusing elements of the transducer assembly on the selected localized target sites.
- View Dependent Claims (29)
Specification