CORONARY VEIN HEMODYNAMIC SENSOR

• US 20090149766A1
• Filed: 10/22/2008
• Published: 06/11/2009
• Est. Priority Date: 12/11/2007
• Status: Abandoned Application

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Shuros, Allan C., Liu, Lili
• Application Number:
  US12/256,203
• Publication Number:
  US 20090149766A1
• Time in Patent Office: Days
• US Class Current: 600/508
• CPC Class Codes: A61B 5/02028 Determining haemodynamic parameters not otherwise provided for, e.g. cardiac contractility or left ventricular ejection fraction
• CPC Class Codes: A61B 5/0215 by means inserted into the body catheters A61M25/00
• CPC Class Codes: A61B 5/053 Measuring electrical impedance or conductance of a portion of the body
• CPC Class Codes: A61B 5/0538 invasively, e.g. using a catheter
• CPC Class Codes: A61B 5/1076 for measuring dimensions inside body cavities, e.g. using catheters A61B3/1005 takes precedence
• CPC Class Codes: A61B 5/6846 specially adapted to be brought in contact with an internal body part, i.e. invasive

Abstract

A system and method for estimating a hemodynamic performance parameter value of a patient'"'"'s heart. The system includes a pulse generator and a medical electrical lead implanted partially within a coronary vein of heart. The lead includes at least one sensor located within the coronary vein configured to generate a signal indicative of at least one dimensional parameter of the coronary vein. Changes in the dimensional parameter during one or more cardiac cycles are measured. The hemodynamic performance parameter is estimated based on the change in the dimensional parameter of the coronary vein.

Claims

1. A method of estimating cardiac hemodynamic performance, the method comprising:

generating a signal indicative of at least one dimensional parameter of a coronary vein of a patient'"'"'s heart using a sensing element on a medical electrical lead, the sensing element positioned within the coronary vein;

estimating a hemodynamic performance parameter as a function of changes in the signal during each of a plurality of cardiac cycles.

2. The method of claim 1 wherein generating the signal indicative of at least one dimensional parameter includes generating a signal indicative of an internal volume of a portion of the coronary vein.

3. The method of claim 1 wherein generating the signal indicative of the internal volume of the portion of the coronary vein includes generating a signal representing localized electrical impedance within the portion of the coronary vein.

4. The method of claim 3 wherein the medical electrical lead has a pair of longitudinally spaced electrodes, the pair of electrodes forming at least a portion of the sensing element.

5. The method of claim 4 wherein generating the signal representing the localized electrical impedance within the portion of the coronary vein includes sending an electric current to one of the pair of electrodes and sensing a corresponding electric field at the other electrode.

6. The method of claim 5 wherein estimating the hemodynamic performance parameter includes subtracting, for each cardiac cycle, a first value of the signal from a second value of the signal, the first value corresponding to an end diastolic period of the cardiac cycle and the second value corresponding to an ejection phase of a systolic period of the cardiac cycle.

7. A method of estimating cardiac hemodynamic performance, the method comprising:

estimating a change in a dimensional parameter of a coronary vein during a cardiac cycle;

estimating a hemodynamic performance parameter based on the change in the dimensional parameter during each of a plurality of cardiac cycles.

8. The method of claim 7 wherein estimating the change in the dimensional parameter includes estimating a change in volume of a portion of the coronary vein during the cardiac cycle.

9. The method of claim 8 wherein estimating the change in volume of the coronary vein includes estimating a change in localized impedance within the portion of the coronary vein during the cardiac cycle.

10. The method of claim 8 wherein estimating the change in volume of the coronary vein includes estimating a difference between a maximum volume and a minimum volume of the portion of the coronary vein during the cardiac cycle.

11. The method of claim 10 wherein the maximum volume of the portion of the coronary vein is measured at an ejection phase of a systolic period of the cardiac cycle, and wherein the minimum volume of the portion of the coronary vein is measured at an end diastolic period of the cardiac cycle.

12. The method of claim 7 wherein estimating the hemodynamic performance parameter includes:

generating a waveform indicating the change in the dimensional parameter during each of the plurality of cardiac cycles;

estimating changes in left ventricular pressure over the plurality of cardiac cycles based on the waveform; and

estimating the hemodynamic performance parameter based on the estimated changes in left ventricular pressure.

13. A method of treating a heart of a patient, the method comprising:

generating a signal indicative of a dimensional parameter of a coronary vein;

estimating a hemodynamic performance parameter as a function of changes in the signal during each of a plurality of cardiac cycles; and

selecting a therapeutic response based at least in part on the cardiac hemodynamic performance parameter.

14. The method of claim 13 wherein selecting the therapeutic response includes selecting a pacing rate.

15. The method of claim 13 wherein selecting the therapeutic response includes adjusting a drug therapy.

16. The method of claim 13 wherein selecting the therapeutic response includes turning pacing therapy on and off for cardiac wall stress adjustment.

17. The method of claim 13 wherein selecting the therapeutic response includes tachycardia therapy discrimination.

18. A system for estimating hemodynamic performance of a heart, the system comprising:

a medical electrical lead configured to be partially implanted in a coronary vein of the heart, the lead including a sensing element configured to generate a signal indicative of a dimensional parameter of the coronary vein; and

a processor operatively coupled to the lead configured to estimate a hemodynamic performance parameter based on changes in the signal during each of a plurality of cardiac cycles.

19. The system of claim 18 wherein the dimensional parameter is an internal volume of a portion of the coronary vein.

20. The system of claim 19 wherein the signal is a localized impedance within a portion of the coronary vein.

21. The system of claim 18 wherein the lead includes a plurality of longitudinally spaced electrodes configured to sense localized impedance in the portion of the coronary vein and to generate the signal therefrom.

22. The system of claim 21 wherein the electrodes have a spacing therebetween of from about 0.5 centimeters to about 2 centimeters.

23. The system of claim 18 wherein:

the lead includes;

an inflatable member configured to radially expand upon introduction of an inflation fluid therein to define a chamber; and

a plurality of electrodes disposed on the lead and configured to sense localized impedance in chamber; and

the signal indicative of the dimensional parameter of the coronary vein is a signal indicative of the localized impedance in the chamber.