System for reversible chemical modulation of neural activity
First Claim
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1. A neural modulation system comprising:
- a signal input structure configured to receive a signal indicative of an activity state of at least a portion of a body of a subject innervated by a peripheral neural structure;
a signal processing portion configured to;
distinguish a first activity state of the at least a portion of the body of the subject innervated by the peripheral neural structure from a second activity state of the at least a portion of the body of the subject innervated by the peripheral neural structure from the signal received at the signal input structure;
generate a chemical blocking agent control signal for driving delivery of a chemical blocking agent adapted to reversibly block conduction in the peripheral neural structure of the subject during at least a portion of the first activity state; and
generate a reversing stimulus control signal for driving delivery of a reversing stimulus to counter the chemical blocking agent used to produce a reversible conduction block in the peripheral neural structure of the subject;
a chemical blocking agent source configured to deliver the chemical blocking agent responsive to the chemical blocking agent control signal; and
a reversing stimulus source configured to produce the reversing stimulus responsive to the reversing stimulus control signal.
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Abstract
Methods and related systems for modulating neural activity by repetitively blocking conduction in peripheral neural structures with chemical blocking agents are disclosed. Methods and systems for reversing effects of chemical blocking agents and/or for producing substantially permanent conduction block are also disclosed.
129 Citations
23 Claims
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1. A neural modulation system comprising:
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a signal input structure configured to receive a signal indicative of an activity state of at least a portion of a body of a subject innervated by a peripheral neural structure; a signal processing portion configured to; distinguish a first activity state of the at least a portion of the body of the subject innervated by the peripheral neural structure from a second activity state of the at least a portion of the body of the subject innervated by the peripheral neural structure from the signal received at the signal input structure; generate a chemical blocking agent control signal for driving delivery of a chemical blocking agent adapted to reversibly block conduction in the peripheral neural structure of the subject during at least a portion of the first activity state; and generate a reversing stimulus control signal for driving delivery of a reversing stimulus to counter the chemical blocking agent used to produce a reversible conduction block in the peripheral neural structure of the subject; a chemical blocking agent source configured to deliver the chemical blocking agent responsive to the chemical blocking agent control signal; and a reversing stimulus source configured to produce the reversing stimulus responsive to the reversing stimulus control signal. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A neural modulation system comprising:
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a signal input structure configured to receive a signal indicative of an activity state of at least a portion of a body of a subject innervated by a peripheral neural structure; a sensor operatively connected to the signal input structure and configured to generate the signal indicative of the activity state of the at least a portion of the body of the subject responsive to activity of the at least a portion of the body of the subject innervated by the peripheral neural structure. a signal processing portion configured to; distinguish a first activity state of the at least a portion of the body of the subject innervated by the peripheral neural structure from a second activity state of the at least a portion of the body of the subject innervated by the peripheral neural structure from the signal received at the signal input structure; generate a chemical blocking agent control signal for driving delivery of a chemical blocking agent adapted to reversibly block conduction in the peripheral neural structure of the subject during at least a portion of the first activity state; and generate a reversing stimulus control signal for driving delivery of a reversing stimulus to counter the chemical blocking agent used to produce a reversible conduction block in the peripheral neural structure of the subject; a chemical blocking agent source configured to deliver the chemical blocking agent responsive to the chemical blocking agent control signal; and a reversing stimulus source configured to produce the reversing stimulus responsive to the reversing stimulus control signal. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. A neural modulation system comprising:
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a signal input structure configured to receive a signal indicative of a physical activity state of at least a portion of a body of a subject innervated by a peripheral neural structure; a signal processing portion configured to; distinguish a first physical activity state of the at least a portion of the body of the subject innervated by the peripheral neural structure from a second activity state of the at least a portion of the body of the subject innervated by the peripheral neural structure from the signal received at the signal input structure; generate a chemical blocking agent control signal for driving delivery of a chemical blocking agent adapted to reversibly block conduction in the peripheral neural structure of the subject during at least a portion of the first physical activity state; and generate a reversing stimulus control signal for driving delivery of a reversing stimulus to counter the chemical blocking agent used to produce a reversible conduction block in the peripheral neural structure of the subject; a chemical blocking agent source configured to deliver the chemical blocking agent responsive to the chemical blocking agent control signal; and a reversing stimulus source configured to produce the reversing stimulus responsive to the reversing stimulus control signal. - View Dependent Claims (22, 23)
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Specification