Cancellous Bone Implant for Cartilage Repair
First Claim
1. A sterile cartilage repair construct derived from cancellous bone for repair of a defect in articular cartilage comprising a base member of mineralized cancellous bone, a cap member mounted to said base member, means to secure said cap member to said bone member, said cap member being constructed of demineralized cancellous bone, treated to be nonosteoinductive and infused with a composition comprising cartilage particles, a biocompatible carrier and at least one growth factor or bioactive peptide.
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Accused Products
Abstract
The invention is directed toward a cartilage repair assembly comprising a shaped allograft construct comprising a cylindrical mineralized cancellous bone base member and a demineralized cancellous bone cap member having a cylindrical top portion and a stem extending from the top portion mounted to the bone base member. The base member has a central bore and a transverse bore which intersect the central bore and the cap member stem has a through going bore which is aligned with the base member transverse bore when the stem is mounted in the central bore to receive a pin member. Milled cartilage particles having a size ranging from 10 to 212 microns are mixed with a biocompatible carrier and a cartilage growth factor, with the mixture being infused in the cap member to generate cartilage growth.
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Citations
25 Claims
- 1. A sterile cartilage repair construct derived from cancellous bone for repair of a defect in articular cartilage comprising a base member of mineralized cancellous bone, a cap member mounted to said base member, means to secure said cap member to said bone member, said cap member being constructed of demineralized cancellous bone, treated to be nonosteoinductive and infused with a composition comprising cartilage particles, a biocompatible carrier and at least one growth factor or bioactive peptide.
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18. A sterile cartilage repair construct comprising a base member of mineralized cancellous bone, a cap member mounted to said base member, said cap member being constructed of demineralized cancellous bone, and infused with a composition comprising cartilage particles, a biocompatible carrier and a chondrogenic growth factor, said base member has a cylindrical shape with a central bore defined therein and a transverse bore intersecting said central bore, said cap member has a cylindrical section with a stem extending from said cylindrical section, said stem defining a through-going bore which can be aligned with said base member transverse bore when said stem is mounted in said central bore and pin means mounted in said stem bore and said base member transverse bore.
- 19. A sterile cartilage repair construct comprising a base member of mineralized allograft cancellous bone, a cap member mounted to said base member, said cap member being constructed of demineralized allograft cancellous bone, treated to be non-osteoinductive and infused with a composition comprising allograft cartilage particles having a size ranging from about 10 to about 212 microns, a biocompatible carrier and a chondrogenic growth factor, said base member has a cylindrical shape with a central bore defined therein and a transverse bore intersecting said central bore and said cap member has a cylindrical section with a planar bottom surface and a stem extending from said cylindrical section, said stem defining a through going bore which can be aligned with said base member transverse bore when said stem is mounted in said central bore and a pin mounted through the aligned bores in said base member and said cap member.
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23. A sterile cartilage repair construct comprising a base member of mineralized allograft cancellous bone, a cap member mounted to said base member, said cap member being constructed of demineralized allograft cancellous bone, treated to be non-osteoinductive and infused with a composition comprising allograft cartilage particles, a biocompatible carrier and a growth factor, said cap member having a cylindrical shape with a central bore defined therein and a transverse bore intersecting said central bore, said base member defining a cylindrical section with a planar bottom surface and a stem extending from said cylindrical section, said stem defining a through going bore which can be aligned with said cap member transverse bore when said base member stem is mounted in said cap member central bore and a pin means mounted through the aligned bores in said base member and said cap member.
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24. A process for constructing a sterile cartilage repair construct comprising the steps of:
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a. milling a mineralized cancellous bone into a cylindrically shaped base member; b. demineralizing a cap member adapted to be mounted to the base member; c. treating the cap member to be non-osteoinductive; d. mounting the cap member to the base member; and e. infusing cartilage particles and at least one cartilage growth factor carried in a biocompatible carrier into the cap member. - View Dependent Claims (25)
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Specification