Method for thermal modulation of neural activity
First Claim
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1. A method of modulating neural activity comprising the steps of:
- producing a reversible conduction block in a peripheral neural structure of a subject with a thermal stimulus while the subject is in a first activity state;
reversing the reversible conduction block in the peripheral neural structure of the subject to permit conduction in the peripheral neural structure when the subject is in a second activity state; and
repeating the steps of producing a reversible conduction block in a peripheral neural structure of a subject with a thermal stimulus while the subject is in a first activity state and reversing the reversible conduction block in the peripheral neural structure of the subject to permit conduction in the peripheral neural structure when the subject is in a second activity state.
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Abstract
Methods and related systems for modulating neural activity by blocking conduction in peripheral neural structures with thermal stimuli are disclosed. Methods and systems for reversing effects of thermal blocking stimuli and/or for producing substantially permanent conduction block are also disclosed.
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Citations
141 Claims
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1. A method of modulating neural activity comprising the steps of:
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producing a reversible conduction block in a peripheral neural structure of a subject with a thermal stimulus while the subject is in a first activity state; reversing the reversible conduction block in the peripheral neural structure of the subject to permit conduction in the peripheral neural structure when the subject is in a second activity state; and repeating the steps of producing a reversible conduction block in a peripheral neural structure of a subject with a thermal stimulus while the subject is in a first activity state and reversing the reversible conduction block in the peripheral neural structure of the subject to permit conduction in the peripheral neural structure when the subject is in a second activity state. - View Dependent Claims (2, 3, 10, 20, 43, 44, 57, 61, 65, 83, 88, 89, 123, 124, 125, 126, 130, 131, 132, 133, 134, 135, 136, 137)
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4-9. -9. (canceled)
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11-19. -19. (canceled)
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21-25. -25. (canceled)
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27-32. -32. (canceled)
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34-41. -41. (canceled)
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45-56. -56. (canceled)
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58-60. -60. (canceled)
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66-82. -82. (canceled)
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84-87. -87. (canceled)
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90-91. -91. (canceled)
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92. A method of modulating neural activity comprising the steps of:
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producing a reversible conduction block in a peripheral neural structure of a subject with a thermal stimulus while the subject is in a first activity state; reversing the reversible conduction block in the peripheral neural structure of the subject to permit conduction in the peripheral neural structure when the subject is in a second activity state by applying a reversing stimulus configured to counter the blocking stimulus used to produce the reversible conduction block in the peripheral neural structure of the subject; and repeating the steps of producing a reversible conduction block in a peripheral neural structure of a subject while the subject is in a first activity state and reversing the reversible conduction block in the peripheral neural structure of the subject to permit conduction in the peripheral neural structure when the subject is in a second activity state. - View Dependent Claims (138, 139)
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93-102. -102. (canceled)
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103. A method of modulating neural activity comprising the steps of:
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producing a reversible conduction block in a peripheral neural structure of a subject with a thermal stimulus while the subject is in a first activity state; reversing the reversible conduction block in the peripheral neural structure of the subject to permit conduction in the peripheral neural structure when the subject is in a second activity state; repeating the steps of producing a reversible conduction block in a peripheral neural structure of a subject while the subject is in a first activity state and reversing the reversible conduction block in the peripheral neural structure of the subject to permit conduction in the peripheral neural structure when the subject is in a second activity state; determining that producing the reversible conduction block in the peripheral neural structure of the subject while the subject is in a first activity state results in a desired effect in the subject; and producing a non-reversible conduction block in the peripheral neural structure of the subject. - View Dependent Claims (117, 140)
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104-116. -116. (canceled)
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118. A method of modulating neural activity comprising the steps of:
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producing a reversible conduction block of a subset of nerve fibers in a peripheral neural structure of a subject with a thermal stimulus while the subject is in a first activity state; reversing the reversible conduction block of the subset of nerve fibers in the peripheral neural structure of the subject to permit conduction in the subset of nerve fibers in the peripheral neural structure when the subject is in a second activity state; and repeating the steps of producing a reversible conduction block in the subset of nerve fibers in a peripheral neural structure of a subject while the subject is in a first activity state and reversing the reversible conduction block in the subset of nerve fibers in the peripheral neural structure of the subject to permit conduction in the subset of nerve fibers in the peripheral neural structure when the subject is in a second activity state. - View Dependent Claims (141)
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119-122. -122. (canceled)
Specification