Simulating Patient-Specific Outcomes
First Claim
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1. A method for predicting cardiovascular risk based a genetic marker status, the method comprising:
- (a) providing a genetic marker status of a subject;
(b) providing a computer model of cardiovascular risk configured to account for the genetic marker, wherein the computer model comprises;
(i) a representation of cholesterol metabolism,(ii) a representation of atherogenesis, and(iii) a representation of plaque stability,wherein a positive genetic marker status is indicated by an alteration in at least one of cholesterol metabolism, atherogenesis and plaque stability; and
(c) simulating and reporting an outcome for the subject.
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Abstract
The invention encompasses systems, methods, and apparatus for predicting clinical outcomes and monitoring an individual'"'"'s response to a therapeutic regimen. The invention further encompasses methods for predicting cardiovascular risk based a genetic marker status and methods for modifying a computer to reflect genetic data and for incorporating genetic markers into a virtual population.
40 Citations
32 Claims
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1. A method for predicting cardiovascular risk based a genetic marker status, the method comprising:
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(a) providing a genetic marker status of a subject; (b) providing a computer model of cardiovascular risk configured to account for the genetic marker, wherein the computer model comprises; (i) a representation of cholesterol metabolism, (ii) a representation of atherogenesis, and (iii) a representation of plaque stability, wherein a positive genetic marker status is indicated by an alteration in at least one of cholesterol metabolism, atherogenesis and plaque stability; and (c) simulating and reporting an outcome for the subject. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A computer-implemented method of predicting a clinical outcome for a subject comprising:
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(a) providing a virtual population comprising a plurality of virtual patients; (b) receiving input data about a subject; (c) selecting one or more virtual patients from the virtual population based on a similarity between each of the selected virtual patients and the input data; (d) applying one or more virtual protocols to the one or more selected virtual patients to generate a set of outputs projecting a clinical outcome for the subject, wherein a set of outputs is generated for each selected virtual patient; and (e) reporting the set of outputs to a user. - View Dependent Claims (10, 11, 12, 13, 14, 15, 16)
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17. A method for modifying a computer model of a biological system to reflect genomic information, the method comprising:
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(a) providing a computer model of a biological system in a computer-readable storage medium; (b) providing a genetic marker having a known association with a clinical phenotype, wherein the genetic marker has a known locus on a chromosome; (c) identifying one or more genes of known biological function that have linkage disequilibrium with the locus of the genetic marker; (d) modifying the computer model to reflect the function of the one or more identified genes; and (e) storing the modified computer model in a computer-readable storage medium. - View Dependent Claims (18, 19, 20, 21, 22)
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23. A method of incorporating a genetic marker into a virtual population, said method comprising:
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(a) providing an original virtual population having a set of population constraints; (b) defining the effect of the genetic marker as one or more new axes of variation to be included in generating a new virtual population; (c) generating virtual patients based on (i) the population constraints of the original virtual population and (ii) the one or more new axes of variation; (d) assigning prevalence weights to the virtual population, incorporating population statistics for the genetic marker as a constraint in the prevalence weighting process; and (e) generating an output comprising the virtual population and associated prevalence weights. - View Dependent Claims (24, 25, 26, 27, 28, 29, 30, 31, 32)
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Specification