Polymeric Composites with a Hydrophilic Coating

• US 20090155595A1
• Filed: 12/12/2007
• Published: 06/18/2009
• Est. Priority Date: 12/12/2007
• Status: Abandoned Application

• Current Assignee: Emembrane Incorporated
• Original Assignee: Emembrane Incorporated
• Inventors: Lee, William
• Application Number:
  US11/954,808
• Publication Number:
  US 20090155595A1
• Time in Patent Office: Days
• US Class Current: 428/412
• CPC Class Codes: A61F 2/1662 Instruments for inserting intraocular lenses into the eye
• CPC Class Codes: A61F 2/1675 with a lubricated inner surface, e.g. the lubricant being coated on the inner surface or being injected through a port
• CPC Class Codes: Y10T 428/31504 Composite [nonstructural laminate]
• CPC Class Codes: Y10T 428/31507 Of polycarbonate
• CPC Class Codes: Y10T 428/3154 Of fluorinated addition polymer from unsaturated monomers
• CPC Class Codes: Y10T 428/31544 Addition polymer is perhalogenated
• CPC Class Codes: Y10T 428/31551 Of polyamidoester [polyurethane, polyisocyanate, polycarbamate, etc.]
• CPC Class Codes: Y10T 428/31725 Of polyamide
• CPC Class Codes: Y10T 428/31779 Next to cellulosic
• CPC Class Codes: Y10T 428/31786 Of polyester [e.g., alkyd, etc.]

Abstract

A polymeric composite including (1) a substrate formed of a moldable polymer; (2) a first polymeric layer containing a base polymer, the first layer adhering to a surface of the substrate by physical entrapment of at least some molecules of the base polymer in the substrate; and (3) a second polymeric layer containing a hydrophilic polymer, the second layer adhering to a surface of the first layer by physical entrapment of at least some molecules of the hydrophilic polymer in the first layer. Also disclosed is a device including such a composite for delivering an intraocular lens.

Claims

1. A polymeric composite comprising:

a substrate formed of a moldable polymer;

a first polymeric layer including a base polymer, the first layer adhering to a surface of the substrate by physical entrapment of at least some molecules of the base polymer in the substrate; and

a second polymeric layer including a hydrophilic polymer, the second layer adhering to a surface of the first layer by physical entrapment of at least some molecules of the hydrophilic polymer in the first layer.

2. The method of claim 1, wherein the moldable polymer is polypropylene, polycarbonate, polyethylene, acryl-butadienestyrene, polyamide, polychlorotrifluoroethylene, polytetrafluoroethylene, polyvinyl chloride, polyvinyldene fluoride, ethylene tetrafluoroethylene, ethylene chlortrifluoroethylene, perfluoroalkoxy, styrene, polymethylpentene, polymethylmetyacrylate, polystyrene, polyetheretherketone, or tetrafluoroethylene.

3. The composite of claim 2, wherein the moldable polymer is polypropylene or polycarbonate.

4. The composite of claim 1, wherein the base polymer is polyurethane, polyacrylate, polymethacrylate, polyvinyl chloride, polyamide, or a polyester/alkyd copolymer.

5. The composite of claim 4, wherein the base polymer is polyurethane.

6. The composite of claim 1, wherein the hydrophilic polymer is polyvinylpyrrolidone, poly-N-vinyl lactams, poly(ethylene oxide), poly(propylene oxide), polyethylene glycol, polyvinyl pyridine, polysaccharides, polycarboxyl methyl cellulose, polypeptides, polyhydroxyethyl methacrylate, poly sodium styrene sulfonate, heparin, polyacrylamides, cellulosic, polyacrylic acid, or polyvinyl ester.

7. The composite of claim 6, wherein the hydrophilic polymer is polyvinylpyrrolidone.

8. The composite of claim 2, wherein the base polymer is polyurethane, polyacrylate, polymethacrylate, polyvinyl chloride, polyamide, or a polyester and alkyd copolymer.

9. The composite of claim 4, wherein the hydrophilic polymer is polyvinylpyrrolidone, poly-N-vinyl lactams, poly(ethylene oxide), poly(propylene oxide), polyethylene glycol, polyvinyl pyridine, polysaccharides, polycarboxyl methyl cellulose, polypeptides, polyhydroxyethyl methacrylate, poly sodium styrene sulfonate, heparin, polyacrylamides, cellulosic, polyacrylic acid, or polyvinyl ester.

10. The composite of claim 6, wherein the moldable polymer is polypropylene, polycarbonate, polyethylene, acryl-butadienestyrene, polyamide, polychlorotrifluoroethylene, polytetrafluoroethylene, polyvinyl chloride, polyvinyldene fluoride, ethylene tetrafluoroethylene, ethylene chlortrifluoroethylene, perfluoroalkoxy, styrene, polymethylpentene, polymethylmetyacrylate, polystyrene, polyetheretherketone, or tetrafluoroethylene.

11. The composite of claim 10, wherein the base polymer is polyurethane, polyacrylate, polymethacrylate, polyvinyl chloride, polyamide, or polyester/alkyd copolymer.

12. The composite of claim 1, wherein the moldable polymer is polypropylene, the base polymer is polyurethane, and the hydrophilic polymer is polyvinylpyrrolidone.

13. A device for delivering an intraocular lens into an eye, said device comprising:

a tapered tube formed of a moldable polymer, the tube having a tube inner surface;

a first polymeric layer including a base polymer, the first polymeric layer having an first polymeric outer surface and a first polymeric inner surface, the first polymeric outer surface adhering to the tube inner surface by a physical entrapment of at least some molecules of the base polymer in the tube; and

a second polymeric layer including a hydrophilic polymer, the second polymeric layer having a second polymeric outer surface adhering to the first polymeric inner surface by physical entrapment of at least some molecules of the hydrophilic polymer in the first polymeric layer.

14. The device of claim 13, wherein the moldable polymer is polypropylene, polycarbonate, polyethylene, acryl-butadienestyrene, polyamide, polychlorotrifluoroethylene, polytetrafluoroethylene, polyvinyl chloride, polyvinyldene fluoride, ethylene tetrafluoroethylene, ethylene chlortrifluoroethylene, perfluoroalkoxy, styrene, polymethylpentene, polymethylmetyacrylate, polystyrene, polyetheretherketone, or tetrafluoroethylene.

15. The device of claim 14, wherein the moldable polymer is polypropylene or polycarbonate.

16. The device of claim 13, wherein the base polymer is polyurethane, polyacrylate, polymethacrylate, polyvinyl chloride, polyamide, or a polyester/alkyd copolymer.

17. The device of claim 16, wherein the base polymer is polyurethane.

18. The device of claim 13, wherein the hydrophilic polymer is polyvinylpyrrolidone, poly-N-vinyl lactams, poly(ethylene oxide), poly(propylene oxide), polyethylene glycol, polyvinyl pyridine, polysaccharides, polycarboxyl methyl cellulose, polypeptides, polyhydroxyethyl methacrylate, poly sodium styrene sulfonate, heparin, polyacrylamides, cellulosic, polyacrylic acid, or polyvinyl ester.

19. The device of claim 18, wherein the hydrophilic polymer is polyvinylpyrrolidone.

20. The device of claim 14, wherein the base polymer is polyurethane, polyacrylate, polymethacrylate, polyvinyl chloride, polyamide, or a polyester and alkyd copolymer.

21. The device of claim 16, wherein the hydrophilic polymer is polyvinylpyrrolidone, poly-N-vinyl lactams, poly(ethylene oxide), poly(propylene oxide), polyethylene glycol, polyvinyl pyridine, polysaccharides, polycarboxyl methyl cellulose, polypeptides, polyhydroxyethyl methacrylate, poly sodium styrene sulfonate, heparin, polyacrylamides, cellulosic, polyacrylic acid, or polyvinyl ester.

22. The device of claim 18, wherein the moldable polymer is polypropylene, polycarbonate, polyethylene, acryl-butadienestyrene, polyamide, polychlorotrifluoroethylene, polytetrafluoroethylene, polyvinyl chloride, polyvinyldene fluoride, ethylene tetrafluoroethylene, ethylene chlortrifluoroethylene, perfluoroalkoxy, styrene, polymethylpentene, polymethylmetyacrylate, polystyrene, polyetheretherketone, or tetrafluoroethylene.

23. The device of claim 22, wherein the base polymer is polyurethane, polyacrylate, polymethacrylate, polyvinyl chloride, polyamide, or polyester/alkyd copolymer.

24. The device of claim 13, wherein the moldable polymer is polypropylene, the base polymer is polyurethane, and the hydrophilic polymer is polyvinylpyrrolidone.

25. The device of claim 13, wherein the second polymeric layer also includes a base polymer.