Biological markers for longevity and diseases and uses thereof
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Accused Products
Abstract
This invention provides methods of using of the sizes and levels of high-density lipoprotein (HDL) and low-density lipoprotein (LDL) particles, the -641 allele of the promoter of the gene encoding apolipoprotein C-3 (APOC-3), the 405 allele of the gene encoding cholesteryl ester transfer protein (CETP), and plasma levels of insulin-like growth factor-1 (IGF-1), adiponectin, CETP and APOC-3, for determining and increasing an individual'"'"'s likelihood of longevity and of retaining cognitive function during aging, and for determining and decreasing an individual'"'"'s likelihood of developing a cardiovascular-, metabolic- or age-related disease.
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Citations
146 Claims
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1-127. -127. (canceled)
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128. An assay for identifying a compound that increases a subject'"'"'s likelihood of longevity, increases a subject'"'"'s likelihood of retaining cognitive function during aging, decreases a subject'"'"'s likelihood of developing a cardiovascular-related disease, decreases a subject'"'"'s likelihood of developing a metabolic syndrome, and/or decreases a subject'"'"'s likelihood of developing an age-related disease, which comprises identifying a compound which:
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(a) increases HDL particle size in the subject'"'"'s plasma, (b) increases LDL particle size in the subject'"'"'s plasma, (c) increases both HDL and LDL particle size in the subject'"'"'s plasma, (d) increases the percentage of large size HDL particles in the subject'"'"'s plasma, (e) increases the percentage of large size LDL particles in the subject'"'"'s plasma, (f) increases the percentage of both large size HDL particles and large size LDL particles in the subject'"'"'s plasma, (g) increases the subject'"'"'s plasma level of HDL, (h) increases the subject'"'"'s plasma level of insulin-like growth factor-1 (IGF-1), (i) increases the subject'"'"'s plasma level of adiponectin, (j) inhibits the activity of the subject'"'"'s cholesteryl ester transfer protein (CETP), and/or, (k) inhibits the activity of the subject'"'"'s apolipoprotein C-3 (APOC-3). - View Dependent Claims (129, 130, 131, 132, 133, 134, 135, 136, 137, 138, 139, 140, 141, 142, 143, 144, 146)
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145. (canceled)
Specification