COMPOSITION AND USE THEREOF IN ENHANCING A THERAPEUTIC EFFECT OF AN ANTIEPILEPTIC DRUG
First Claim
1. A method of use of a glucocorticoid receptor antagonist for enhancing a therapeutic effect of an antiepileptic drug in treating a seizure in a status epilepticus in an animal, the method comprising:
- administering the glucocorticoid receptor antagonist; and
administering the antiepileptic drug, wherein the glucocorticoid receptor antagonist is administered in an amount effective to enhance the therapeutic effect of the antiepileptic drug in treating the seizure in the status-epilepticus in the animal, provided that the glucocorticoid receptor antagonist is administered to the animal prior to, contemporaneous with, or subsequent to administering the antiepileptic drug, and thereby enhancing the therapeutic effect of the antiepileptic drug.
2 Assignments
0 Petitions
Accused Products
Abstract
A composition and a method for the use of the composition for enhancing a therapeutic effect of an antiepileptic drug in treating a seizure in a status epilepticus in an animal. A composition includes a glucocorticoid receptor antagonist and an antiepileptic drug, wherein the glucocorticoid receptor antagonist is present in an amount effective to enhance a therapeutic effect of the antiepileptic drug in treating a seizure in a status-epilepticus in an animal. A method of use of a glucocorticoid receptor antagonist for enhancing a therapeutic effect of an antiepileptic drug in treating a seizure in a status epilepticus in an animal, the method includes administering the glucocorticoid receptor antagonist and the antiepileptic drug, wherein the glucocorticoid receptor antagonist is administered to the animal prior to, contemporaneous with, or subsequent to administering the antiepileptic drug in an amount effective to enhance the therapeutic effect of the antiepileptic drug.
14 Citations
32 Claims
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1. A method of use of a glucocorticoid receptor antagonist for enhancing a therapeutic effect of an antiepileptic drug in treating a seizure in a status epilepticus in an animal, the method comprising:
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administering the glucocorticoid receptor antagonist; and administering the antiepileptic drug, wherein the glucocorticoid receptor antagonist is administered in an amount effective to enhance the therapeutic effect of the antiepileptic drug in treating the seizure in the status-epilepticus in the animal, provided that the glucocorticoid receptor antagonist is administered to the animal prior to, contemporaneous with, or subsequent to administering the antiepileptic drug, and thereby enhancing the therapeutic effect of the antiepileptic drug. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 11, 12, 13, 14, 15, 16, 17, 31, 32)
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10. (canceled)
- 18. A composition comprising a glucocorticoid receptor antagonist and an antiepileptic drug, wherein the glucocorticoid receptor antagonist is present in an amount effective to enhance a therapeutic effect of the antiepileptic drug in treating a seizure in a status-epilepticus in an animal.
- 29. A kit for enhancing a therapeutic effect of an antiepileptic drug in treating a seizure in a status epilepticus in an animal, the kit comprises mifepristone, an anti epileptic drug and a pharmaceutical carrier.
Specification