Ginkgolide Compounds, Compositions, And Extracts, And Uses Thereof
3 Assignments
0 Petitions
Accused Products
Abstract
The present invention relates to Ginkgolide derivatives, compositions and extracts comprising one or more Ginkgolides and/or derivatives thereof and methods of use of the compositions to treat neurological disorders and as imaging agents.
28 Citations
47 Claims
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1. A compound having the formula:
- 2. A composition consisting essentially of two or more structurally distinct compounds, each having the formula:
- 12. A composition consisting essentially of a first compound having the formula:
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13. (canceled)
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16-17. -17. (canceled)
- 18. A composition consisting essentially of Ginkgolide A and Ginkgolide J.
- 19. A composition consisting essentially of (i) an antioxidant, a pharmaceutical carrier, or a combination thereof and (ii) two or more structurally distinct compounds, each having the formula:
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26-28. -28. (canceled)
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30. An extract comprising more than 10% terpene trilactones, wherein the proportion of terpene trilactones, by weight of the total amount of terpene trilactiones, is
from about 20% to about 30% or about 52% to about 62% bilobalide, from about 10% to about 20% or about 37% to about 47% ginkgolide A, from about 5% to about 20% ginkgolide B, from about 5% to about 20% ginkgolide C, and from about 1% to about 8% ginkgolide J, and wherein the percentages of bilobalide, ginkgolide A, ginkgolide B, ginkgolide C and ginkgolide J add up to 100%.
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31. (canceled)
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34. A method of treating a disease or disorder comprising administering to a subject an effective amount of
(i) an enriched Ginkgo biloba extract comprising at least about 60% terpene trilactones; - or
(ii) a compound having the formula; - View Dependent Claims (35)
- or
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36-39. -39. (canceled)
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40. A method for protecting a neuron against neuronal cell death or long term potentiation impairment by beta amyloid protein comprising contacting the neuron with
(i) an enriched Ginkgo biloba extract comprising at least about 60% terpene trilactones; - or
(ii) a compound having the formula;
- or
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41. A method for stimulating axonal out growth of a neuron comprising contacting the neuron with
(i) an enriched Ginkgo biloba extract comprising at least about 60% terpene trilactones; - or
(ii) a compound having the formula;
- or
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42-43. -43. (canceled)
- 44. A method of identifying a receptor that binds a compound that protects against neuronal cell death or long term potentiation impairment by beta amyloid protein comprising administering the phosphodiesterase inhibitor to a subject a compound having the formula:
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45. (canceled)
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47-57. -57. (canceled)
Specification