SURFACE MODIFIED BIOMEDICAL DEVICES

• US 20090156745A1
• Filed: 12/08/2008
• Published: 06/18/2009
• Est. Priority Date: 12/14/2007
• Status: Abandoned Application

• Current Assignee: Weihong Lang, Yu-Chin Lai
• Original Assignee: Weihong Lang, Yu-Chin Lai
• Inventors: Lai, Yu-Chin, Lang, Weihong
• Application Number:
  US12/329,710
• Publication Number:
  US 20090156745A1
• Time in Patent Office: Days
• US Class Current: 525/205
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: C08L 101/02 characterised by the presence of specified groups , e.g. terminal or pendant functional groups
• CPC Class Codes: C08L 39/06 Homopolymers or copolymers of N-vinyl-pyrrolidones

Abstract

A surface modified biomedical device is provided comprising a biomedical device having a coating on at least a portion thereof, the coating comprising one or more hydrophilic polymers having one or more non-ethylenically-unsaturated carboxylic acid terminated groups.

Claims

1. A method for improving the wettability of a biomedical device, the method comprising the step of contacting a surface of the biomedical device with a composition comprising one or more hydrophilic polymers having one or more non-ethylenically-unsaturated carboxylic acid terminated groups.

2. The method of claim 1, wherein the biomedical device is a contact lens.

3. The method of claim 1, wherein the biomedical device is a silicone hydrogel contact lens.

4. The method of claim 1, wherein the hydrophilic polymer comprises one or more units derived from N-vinylpyrrolidone.

5. The method of claim 1, wherein the hydrophilic polymer comprises one or more units derived from N-vinylpyrrolidone, alkylene oxides, glyceryl methacrylate, glyceryl acrylate, dimethyl methacrylamide, dimethyl acrylamide, 2-hydroxyethyl methacrylate, 2-hydroxyethyl acrylate, erythritol methacrylate, erythritol acrylate, xylitol methacrylate, xylitol acrylate, sorbitol methacrylate, sorbitol acrylate, derivatives thereof or mixtures thereof.

6. The method of claim 1, wherein the hydrophilic polymer is a reaction product of a hydroxyl-terminated oligomer or polymer having a plurality of hydrophilic groups with a saturated, cyclic anhydride.

7. The method of claim 5, wherein the hydroxyl-terminated oligomer or polymer comprises one or more units derived from N-vinylpyrrolidone.

8. The method of claim 5, wherein the saturated, cyclic anhydride is selected from the group consisting of succinic anhydride, glutaric anhydride and adipic anhydride.

9. The method of claim 1, wherein the hydrophilic polymer has one non-ethylenically-unsaturated carboxylic acid terminated group.

10. The method of claim 1, wherein the hydrophilic polymer is terminated on each end with a non-ethylenically-unsaturated carboxylic acid terminal group.

11. A surface modified biomedical device comprising a biomedical device having a coating on a surface thereof, the coating comprising one or more hydrophilic polymers having one or more non-ethylenically-unsaturated carboxylic acid terminated groups.

12. The surface modified biomedical device of claim 11, wherein the biomedical device is a contact lens.

13. The surface modified biomedical device of claim 11, wherein the biomedical device is a silicone hydrogel contact lens.

14. The surface modified biomedical device of claim 11, wherein the hydrophilic polymer comprises one or more units derived from N-vinylpyrrolidone.

15. The surface modified biomedical device of claim 11, wherein the hydrophilic polymer comprises one or more units derived from N-vinylpyrrolidone, alkylene oxides, glyceryl methacrylate, glyceryl acrylate, dimethyl methacrylamide, dimethyl acrylamide, 2-hydroxyethyl methacrylate, 2-hydroxyethyl acrylate, erythritol methacrylate, erythritol acrylate, xylitol methacrylate, xylitol acrylate, sorbitol methacrylate, sorbitol acrylate, derivatives thereof or mixtures thereof.

16. The surface modified biomedical device of claim 11, wherein the hydrophilic polymer is a reaction product of a hydroxyl-terminated oligomer or polymer having a plurality of hydrophilic groups with a saturated, cyclic anhydride.

17. The surface modified biomedical device of claim 16, wherein the hydroxyl-terminated oligomer or polymer comprises one or more units of N-vinylpyrrolidone.

18. The surface modified biomedical device of claim 16, wherein the saturated, cyclic anhydride is selected from the group consisting of succinic anhydride, glutaric anhydride and adipic anhydride.

19. The surface modified biomedical device of claim 11, wherein the hydrophilic polymer has one non-ethylenically-unsaturated carboxylic acid terminated group.

20. The surface modified biomedical device of claim 11, wherein the hydrophilic polymer is terminated on each end with a non-ethylenically-unsaturated carboxylic acid terminal group.

21. A method of forming a surface modified biomedical device, the method comprising contacting a surface of a biomedical device with a composition comprising one or more hydrophilic polymers having one or more non-ethylenically-unsaturated carboxylic acid terminated groups.

22. The method of claim 21, wherein the biomedical device is a contact lens.

23. The method of claim 21, wherein the hydrophilic polymer comprises one or more units derived from N-vinylpyrrolidone.

24. The method of claim 21, wherein the hydrophilic polymer comprises one or more derived from N-vinylpyrrolidone, alkylene oxides, glyceryl methacrylate, glyceryl acrylate, dimethyl methacrylamide, dimethyl acrylamide, 2-hydroxyethyl methacrylate, 2-hydroxyethyl acrylate, erythritol methacrylate, erythritol acrylate, xylitol methacrylate, xylitol acrylate, sorbitol methacrylate, sorbitol acrylate, derivatives thereof or mixtures thereof.

25. The method of claim 21, wherein the hydrophilic polymer is a reaction product of a hydroxyl-terminated oligomer or polymer having a plurality of hydrophilic groups with a saturated, cyclic anhydride.