Controlling Transfer of Objects Affecting Optical Characteristics
First Claim
1. An implantable article comprising:
- first and second parts;
each of the first and second parts including a respective container and being operable as an optical cavity with a respective optical spectrum characteristic that can be affected by presence of spectrum-affecting objects in the container;
the respective container having a respective set of one or more bounding regions through which objects in bodily fluid can transfer between the container'"'"'s interior and exterior when the article is implanted in a body; and
first and second fluidic components that control transfer of objects in bodily fluid through the respective bounding regions of the first and second parts, respectively;
the first fluidic component permitting transfer of a first set of the spectrum-affecting objects into the first container at a more rapid rate than spectrum-affecting objects not in the first set;
the second fluidic component permitting transfer of a second set of the spectrum-affecting objects into the second container at a more rapid rate than spectrum-affecting objects not in the second set;
the first and second sets of spectrum-affecting objects both including a shared subset;
the first set including a non-shared subset that the second set does not include;
objects that are instances of an analyte type being predominantly in the non-shared subset.
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Accused Products
Abstract
An implantable product such as an article, device, or system can include analyte and non-analyte containers in parts that can be operated as optical cavities. The product can also include fluidic components such as filter assemblies that control transfer of objects that affect or shift spectrum features or characteristics such as by shifting transmission mode peaks or reflection mode valleys, shifting phase, reducing maxima or contrast, or increasing intermediate intensity width such as full width half maximum (FWHM). Analyte, e.g. glucose molecules, can be predominantly included in a set of objects that transfer more rapidly into the analyte container than other objects, and can have a negligible or zero rate of transfer into the non-analyte container; objects that transfer more rapidly into the non-analyte container can include objects smaller than the analyte or molecules of a set of selected types, including, e.g., sodium chloride. Output light from the containers accordingly includes information about analyte.
120 Citations
23 Claims
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1. An implantable article comprising:
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first and second parts;
each of the first and second parts including a respective container and being operable as an optical cavity with a respective optical spectrum characteristic that can be affected by presence of spectrum-affecting objects in the container;
the respective container having a respective set of one or more bounding regions through which objects in bodily fluid can transfer between the container'"'"'s interior and exterior when the article is implanted in a body; andfirst and second fluidic components that control transfer of objects in bodily fluid through the respective bounding regions of the first and second parts, respectively;
the first fluidic component permitting transfer of a first set of the spectrum-affecting objects into the first container at a more rapid rate than spectrum-affecting objects not in the first set;
the second fluidic component permitting transfer of a second set of the spectrum-affecting objects into the second container at a more rapid rate than spectrum-affecting objects not in the second set;
the first and second sets of spectrum-affecting objects both including a shared subset;
the first set including a non-shared subset that the second set does not include;
objects that are instances of an analyte type being predominantly in the non-shared subset. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A method comprising:
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controlling transfer of objects in bodily fluid between interior and exterior of at least two of a set of containers implanted in a body;
each container being in a respective part of an implantable article, the respective part being operable as an optical cavity;
each of first and second containers in the set having a respective set of one or more bounding regions through which objects in bodily fluid can transfer between the container'"'"'s exterior and interior; andoperating the respective part of each of at least the first and second containers as an optical cavity to provide output light in which a respective spectrum characteristic is affected by presence of spectrum-affecting objects in the container; the act of controlling transfer of objects in bodily fluid comprising; permitting transfer of a first set of the spectrum-affecting objects into the first container through its respective set of bounding regions at a more rapid rate than spectrum-affecting objects that are not in the first set; and permitting transfer of a second set of the spectrum-affecting objects into the second container through its respective set of bounding regions at a more rapid rate than spectrum-affecting objects that are not in the second set; the first and second sets of spectrum-affecting objects both including a shared subset;
the first set including a non-shared subset that the second set does not include;
objects that are instances of an analyte type being predominantly in the non-shared subset;
output light from the first and second containers together including information about spectrum-affecting objects of the analyte type. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21)
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22. A method comprising:
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controlling transfer of objects in bodily fluid between interior and exterior of at least two of a set of containers implanted in a body;
each container being in a respective part of an implantable article, the respective part being operable as an optical cavity that provides output light;
each of first and second containers in the set of containers having a respective set of one or more bounding regions through which objects in bodily fluid can transfer between the container'"'"'s exterior and interior; andoperating the respective part of each of at least the first and second containers to provide output light in which a respective optical spectrum feature is shifted by presence of spectrum-shifting objects in the container; the act of controlling transfer of objects in bodily fluid comprising; permitting transfer of a first set of the spectrum-shifting objects into the first container through its respective set of bounding regions at a more rapid rate than spectrum-shifting objects that are not in the first set; and permitting transfer of a second set of the spectrum-shifting objects into the second container through its respective set of bounding regions at a more rapid rate than spectrum-shifting objects that are not in the second set; the first and second sets of spectrum-shifting objects both including a shared subset;
the first set including a non-shared subset that the second set does not include;
objects that are in an analyte set being predominantly in the non-shared subset;
output light from the first and second containers together including information about spectrum-shifting objects in the analyte set.
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23. A method of making an implantable product, the method comprising:
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producing an optical cavity structure that includes first and second optical cavity parts, each operable as an optical cavity;
the act of producing the optical cavity structure comprising;producing each of the first and second optical cavity parts to include a respective container having a set of one or more bounding regions through which objects in bodily fluid can transfer between the container'"'"'s interior and exterior when the product is implanted in a body and, when operated as an optical cavity, to have a respective optical spectrum characteristic that can be affected by presence of spectrum-affecting objects in the container; and attaching first and second fluidic components to the first and second parts, respectively; when the product is implanted in a body, the first and second fluidic components controlling transfer of objects in bodily fluid through the respective bounding regions of the first and second parts, respectively;
the first fluidic component permitting transfer of a first set of the spectrum-affecting objects into the first container at a more rapid rate than spectrum-affecting objects not in the first set;
the second fluidic component permitting transfer of a second set of the spectrum-affecting objects into the second container at a more rapid rate than spectrum-affecting objects not in the second set;
the first and second sets of spectrum-affecting objects both including a shared subset;
the first set including a non-shared subset that the second set does not include;
objects that are instances of an analyte type being predominantly in the non-shared subset.
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Specification