Fiber Optic Interrogated Microslide, Microslide Kits and Uses Thereof
First Claim
1. A fiber optic interrogated microslide having zero thickness optical equivalence, the microslide comprising:
- a substrate comprising an upper surface and a lower surface; and
a plurality of optic fibers integrally disposed in the substrate, plural optic fibers optically coupling the upper and lower surfaces of the substrate, wherein optically coupling the upper and lower surfaces of the substrate provides for substantially zero thickness optical interrogation.
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Accused Products
Abstract
The present invention provides a substrate that overcomes the performance limitations of conventional microscope slides, microarrays, or microtiter plates when optically interrogated through the thickness of the substrate. With conventional microscope slides, image quality and resolution are degraded as a result of distortions introduced by imaging through the thickness of the glass. Fiber Optic Interrogated Microslides (FOI) consist of many fiber optics that have been fused together. When sliced and polished to form microscope slides, the fibers effectively transfer optical images from one surface of the microslide to the other. The finished microslide is the optical equivalent of a zero thickness window. The image of an object on the top surface is transferred to the bottom surface allowing it to be viewed without focusing through the thickness of the slide. In addition to providing improved image quality, FOI microslides allow objects to be directly imaged without complex and expensive focusing optics.
26 Citations
53 Claims
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1. A fiber optic interrogated microslide having zero thickness optical equivalence, the microslide comprising:
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a substrate comprising an upper surface and a lower surface; and a plurality of optic fibers integrally disposed in the substrate, plural optic fibers optically coupling the upper and lower surfaces of the substrate, wherein optically coupling the upper and lower surfaces of the substrate provides for substantially zero thickness optical interrogation. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46)
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47. An imaging device having a specimen supporting substrate, the substrate providing spatial translation of a viewing plane of the imaging device, the substrate comprising:
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first and second surfaces, one of which is conformal to the viewing plane; a plurality of optical micro channels between the first and second surface providing said viewing plane translation; the other of said surfaces providing support for the specimen. - View Dependent Claims (48)
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49. A specimen supporting substrate, the substrate providing spatial translation of a viewing plane of an imaging device, the substrate comprising:
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first and second surfaces, one of which is conformal to the viewing plane; a plurality of optical micro channels between the first and second surface providing said viewing plane translation. - View Dependent Claims (50)
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51. A specimen supporting substrate, the substrate providing spatial translation of a viewing plane, the substrate comprising:
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first and second surfaces, one of which is conformal to the viewing plane; a plurality of optical micro channels between the viewing plane conformal surface and the other surface providing said viewing plane translation there between; a sensor array on the surface conformal to the viewing plane; and the other of said surfaces providing support for the specimen. - View Dependent Claims (52, 53)
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Specification