BONE MARROW TRANSPLANTATION FOR TREATMENT OF STROKE

• US 20090162327A1
• Filed: 10/10/2008
• Published: 06/25/2009
• Est. Priority Date: 05/14/1999
• Status: Abandoned Application

• Current Assignee: Henry Ford Health System
• Original Assignee: Theradigm, Inc.
• Inventors: Li, Yi, Chopp, Michael
• Application Number:
  US12/249,687
• Publication Number:
  US 20090162327A1
• Time in Patent Office: Days
• US Class Current: 424/93.700
• CPC Class Codes: A61K 35/28 Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 25/16 Anti-Parkinson drugs
• CPC Class Codes: A61P 25/28 for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

There is provided a treatment for patients suffering from neurodegenerative disease or neural injury including the steps of transplanting cultured bone marrow cells into the spinal cord or brain or injecting intravascularly bone marrow cells of a patient in need. Also provided is a method of activating the differentiation of neural cells in an injured brain including the steps of transplanting bone marrow cells adjacent to the injured brain cells and activating the endogenous central nervous system stem cells to differentiate into neurons. A method of treating injured brain or spinal cord cells is also provided including the steps of transplanting bone marrow cells near the injured brain cells and generating new neurons at the location of transplantation. A method of treating injured brain or spinal cord cells with a composite of MSCs and neurospheres.

Claims

1. A treatment for a patient suffering from a brain or spinal cord injury or neurodegenerative disease comprising the steps of:

intravascular administration or transplanting of cultured bone marrow cells into the brain or spinal cord of the patient in need; and

generating new neurons in the brain of the patient.

3. The method of claim 1 wherein the transplanting cultured bone marrow cells is near the injured brain cells;

and wherein the step of generating new neurons occurs at the location of transplantation or of intravascular (intraarterial, intravenous) injection of cultured bone marrow cells.

2. A method of activating the differentiation of neural cells in an injured brain or spinal cord comprising the steps of:

transplanting bone marrow cells adjacent to the injured brain cells; and

activating the endogenous central nervous system stem cells to differentiate into neurons.

4. A method of treating injured brain or spinal cord by injecting or transplanting a composite of MSC and neurospheres.