BIVALENT, BISPECIFIC ANTIBODIES
First Claim
Patent Images
1. A bivalent, bispecific antibody, comprising:
- a) the light chain and heavy chain of an antibody specifically binding to a first antigen; and
b) the light chain and heavy chain of an antibody specifically binding to a second antigen, wherein the variable domains VL and VH from the antibody specifically binding to a second antigen are replaced by each other.
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Abstract
The present invention relates to novel domain exchanged, bivalent, bispecific antibodies, their manufacture and use.
53 Citations
14 Claims
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1. A bivalent, bispecific antibody, comprising:
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a) the light chain and heavy chain of an antibody specifically binding to a first antigen; and b) the light chain and heavy chain of an antibody specifically binding to a second antigen, wherein the variable domains VL and VH from the antibody specifically binding to a second antigen are replaced by each other. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 11, 12, 13, 14)
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10. A host cell comprising:
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vectors comprising nucleic acid molecules encoding the light chain and heavy chain of an antibody specifically binding to a first antigen; vectors comprising nucleic acid molecules encoding the light chain and heavy chain of an antibody specifically binding to a second antigen, wherein the variable domains VL and VH from the antibody specifically binding to a second antigen are replaced by each other.
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Specification