Anti-IL-23 Antibodies, Compositions, Methods and Uses
First Claim
Patent Images
1. An isolated IL-23p19 antibody, wherein said antibody binds to human IL-23p19 or a fragment thereof at one or more of amino acid residues selected from the group consisting of residues 93-102, 93-110, and/or 127-137 of SEQ ID NO:
- 1.
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Accused Products
Abstract
An anti-IL-23p19 antibody, including isolated nucleic acids that encode at least one anti-IL-23p19 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
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Citations
69 Claims
- 1. An isolated IL-23p19 antibody, wherein said antibody binds to human IL-23p19 or a fragment thereof at one or more of amino acid residues selected from the group consisting of residues 93-102, 93-110, and/or 127-137 of SEQ ID NO:
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4. An isolated IL-23p19 antibody, comprising at least one light chain variable region, said light chain variable region comprising at least one member from the group consisting of:
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a complementarity determining region light chain 1 (CDRL1) amino acid sequence selected from the group consisting of SEQ ID NOS;
9, 19, 29, and 39;a CDRL2 amino acid sequence selected from the group consisting of SEQ ID NOS;
10, 20, 30, and 40; anda CDRL3 amino acid sequence selected from the group consisting of SEQ ID NOS;
11, 21, 31, and 41. - View Dependent Claims (6, 7)
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5. An isolated IL-23p19 antibody, comprising at least one heavy chain variable region, said heavy chain variable region comprising at least one member from the group consisting of:
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a complementarity determining region heavy chain 1 (CDRH1) amino acid sequence selected from the group consisting of SEQ ID NOS;
4, 14, 24, and 34;a CDRH2 amino acid sequence selected from the group consisting of SEQ ID NOS;
5, 15, 25, and 35; anda CDRH3 amino acid sequence selected from the group consisting of SEQ ID NOS;
6, 16, 26, and 36.
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8. An isolated IL-23p19 antibody, comprising at least one light chain variable region, said light chain variable region comprising:
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a complementarity determining region light chain 1 (CDRL1) amino acid sequence selected from the group consisting of SEQ ID NOS;
9, 19, 29, and 39;a CDRL2 amino acid sequence selected from the group consisting of SEQ ID NOS;
10, 20, 30, and 40; anda CDRL3 amino acid sequence selected from the group consisting of SEQ ID NOS;
11, 21, 31, and 41. - View Dependent Claims (10)
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9. An isolated IL-23p19 antibody, comprising at least one heavy chain variable region, said heavy chain variable region comprising:
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a complementarity determining region heavy chain 1 (CDRH1) amino acid sequence selected from the group consisting of SEQ ID NOS;
4, 14, 24, and 34;a CDRH2 amino acid sequence selected from the group consisting of SEQ ID NOS;
5, 15, 25, and 35; anda CDRH3 amino acid sequence selected from the group consisting of SEQ ID NOS;
6, 16, 26, and 36.
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11. An isolated IL-23p19 antibody, comprising a light chain variable region amino acid sequence selected from the group consisting of SEQ ID NOS:
- 8, 18, 28, and 38.
- View Dependent Claims (13, 14, 19)
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12. An isolated IL-23p19 antibody, comprising a heavy chain variable region amino acid sequence selected from the group consisting of SEQ ID NOS:
- 3, 13, 23, and 33.
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15. An isolated IL-23p19 antibody, comprising a light chain variable amino acid sequence having at least 90% identity to any of the amino acid sequences selected from the group consisting of SEQ ID NOS:
- 8, 18, 28, and 38.
- View Dependent Claims (17, 20)
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16. An isolated IL-23p19 antibody, comprising a heavy chain variable amino acid sequence having at least 90% identity to any of the amino acid sequences selected from the group consisting of SEQ ID NOS:
- 3, 13, 23, and 33.
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25. An isolated nucleic acid molecule comprising at least one of:
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a light chain nucleotide sequence selected from the group consisting of SEQ ID NOS;
7, 17, 27, and 37; anda heavy chain nucleotide sequence selected from the group consisting of SEQ ID NOS;
2, 12, 22, and 32. - View Dependent Claims (26, 27, 28, 29)
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43. An isolated IL-23p19 antibody, comprising a light chain variable amino acid sequence encoded by the nucleotide sequence selected from the group consisting of SEQ ID NOS:
- 7, 17, 27, and 37.
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44. An isolated IL-23p19 antibody, comprising a heavy chain variable amino acid sequence encoded by the nucleotide sequence selected from the group consisting of SEQ ID NOS:
- 2, 12, 22, and 32.
- 47. An isolated IL-23p19 antibody, comprising a light chain variable region encoding sequence having at least 90% identity to any of the nucleotide sequences selected from the group consisting of SEQ ID NOS:
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48. An isolated IL-23p19 antibody, comprising a heavy chain variable region encoding sequence having at least 90% identity to any of the nucleotide sequences selected from the group consisting of SEQ ID NOS:
- 2, 12, 22, and 32.
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69. Any invention described herein.
Specification