CHONDROCYTE THERAPEUTIC DELIVERY SYSTEM
First Claim
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1. A therapeutic system comprising:
- (a) a housing configured to allow passage of a therapeutic agent; and
(b) a genetically altered chondrocyte retained within the housing, the genetically altered chondrocyte modified to express a therapeutic agent.
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Abstract
Systems and methods for modifying the environment of target cell using genetically altered chondrocytes are provided. The genetically engineered chondrocytes can be used to express a therapeutic agent in a subject, including in an environment typically associated with chondrocytes and in an environment not typically associated with chondrocytes.
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Citations
45 Claims
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1. A therapeutic system comprising:
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(a) a housing configured to allow passage of a therapeutic agent; and (b) a genetically altered chondrocyte retained within the housing, the genetically altered chondrocyte modified to express a therapeutic agent. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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23. A method for modifying an environment of a target cell associated with a disorder using a genetically altered chondrocyte, comprising:
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providing a housing configured to retain a genetically altered chondrocyte; providing a genetically altered chondrocyte retained within the housing, the genetically altered chondrocyte altered to express a therapeutic agent; delivering the housing and genetically altered chondrocyte to the environment of a target cell associated with a disorder; and expressing the therapeutic agent to a level sufficient to modify the environment surrounding the target cell. - View Dependent Claims (24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34)
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35. A method for ameliorating a disorder or injury in a subject, comprising:
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providing a housing configured to retain a genetically altered chondrocyte; providing a genetically altered chondrocyte retained within the housing, the genetically altered chondrocyte altered to express a therapeutic agent; delivering the housing and genetically altered chondrocyte into a target region of the subject; and expressing the therapeutic agent in the target region at a level sufficient to ameliorate the disorder. - View Dependent Claims (36, 37, 38, 39, 40, 41, 42, 43, 44, 45)
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Specification