miR-20 Regulated Genes and Pathways as Targets for Therapeutic Intervention
First Claim
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1. A method of modulating gene expression in a cell comprising administering to the cell an amount of an isolated nucleic acid comprising a miR-20 nucleic acid sequence in an amount sufficient to modulate the expression of one or more genes identified in Table 1, 3, 4, or 5.
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Abstract
The present invention concerns methods and compositions for identifying genes or genetic pathways modulated by miR-20a, using miR-20a to modulate a gene or gene pathway, using this profile in assessing the condition of a patient and/or treating the patient with an appropriate miRNA.
166 Citations
51 Claims
- 1. A method of modulating gene expression in a cell comprising administering to the cell an amount of an isolated nucleic acid comprising a miR-20 nucleic acid sequence in an amount sufficient to modulate the expression of one or more genes identified in Table 1, 3, 4, or 5.
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44. A method of treating a patient diagnosed with or suspected of having or suspected of developing a pathological condition or disease related to a gene modulated by a miRNA comprising the steps of:
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(a) administering to the patient an amount of an isolated nucleic acid comprising a miR-20 nucleic acid sequence in an amount sufficient to modulate a cellular pathway or a physiologic pathway; and (b) administering a second therapy, wherein the modulation of the cellular pathway or physiologic pathway sensitizes the patient to the second therapy.
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45-49. -49. (canceled)
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50. A method of assessing a cell, tissue, or subject comprising assessing expression of miR-20 in combination with assessing expression of one or more gene from Table 1, 3, 4, or 5 in at least one sample.
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51. (canceled)
Specification