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N-Phenyl Benzamide Derivatives as Sirtuin Modulators

  • US 20090163476A1
  • Filed: 03/03/2006
  • Published: 06/25/2009
  • Est. Priority Date: 03/03/2005
  • Status: Abandoned Application
First Claim
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1. A compound represented by Structural Formula (III):

  • or a salt thereof, where;

    Ring A is optionally substituted;

    R5 and R6 are independently —

    H, a substituted or unsubstituted alkyl group, a substituted or unsubstituted aryl group or a substituted or unsubstituted heterocyclic group;

    R7, R9, R10 and R11 are independently selected from the group consisting of —

    H, halogen, —

    R5, —

    OR5, —

    CN, —

    CO2R5, —

    OCOR5, —

    OCO2R5, —

    C(O)NR5R6, —

    OC(O)NR5R6, —

    C(O)R5, —

    COR5, —

    SR5, —

    OSO3H, —

    S(O)nR5, —

    S(O)nOR5, —

    S(O)nNR5R6, —

    NR5R6, —

    NR5C(O)OR6, —

    NR5C(O)R6 and —

    NO2;

    R8 is a polycyclic aryl group; and

    n is 1 or 2.

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