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Novel Protein Kinase B Inhibitors - 060

  • US 20090163524A1
  • Filed: 10/10/2008
  • Published: 06/25/2009
  • Est. Priority Date: 10/11/2007
  • Status: Active Grant
First Claim
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1. A compound of Formula (I), or a pharmaceutically acceptable salt thereof:

  • wherein;

    Y represents CH or N;

    Z1-Z2 represents a group selected from C(R6)═

    CH, N═

    CH and C(R6)═

    N;

    whereR6 represents hydrogen, fluoro, chloro, bromo, cyano, methyl, ethyl, difluoromethyl, trifluoromethyl or cyclopropyl;

    n is 0, 1 or 2;

    R1 represents C1-4alkyl, C2-4alkenyl, C2-4alkynyl, C1-4alkoxy, C1-4alkoxyC1-4alkyl, fluoroC1-4alkyl, aminoC1-4alkyl, hydroxyC1-4alkyl, cyano, cyanoC1-4alkyl, C3-6cycloalkyl, —

    (CH2)pNHCOCH3, —

    (CH2)pNHSO2CH3, —

    (CH2)pNHCONH2, —

    (CH2)pNHCONR2R3, —

    (CH2)pNR2R3, —

    (CH2)pSO2NH2, —

    (CH2)pSO2NR2R3, —

    (CH2)pCONH2, —

    (CH2)pCONR2R3 or —

    (CH2)p

    R7;

    wherep is 0, 1, 2 or 3;

    R2 represents hydrogen or C1-3alkyl;

    R3 represents C1-3alkyl; and

    R7 represents phenyl;

    R7 represents a 5 or 6 membered monocyclic heteroaryl ring which comprises 1, 2 or 3 heteroatoms selected from O, N or S;

    orR7 represents a monocyclic 4, 5, or 6 membered heterocyclic ring which comprises 1, 2 or 3 heteroatoms selected from O, N or S;

    wherein R7 is optionally substituted by 1 or 2 substituents selected from C1-4alkyl, trifluoromethyl, C1-4alkoxy, fluoro, chloro, bromo, and cyano;

    R4 represents hydrogen, fluoro, chloro, bromo, cyano or trifluoromethyl; and

    R5 represents hydrogen, fluoro, chloro or bromo.

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