Method For Altering The Lifespan Of Eukaryotic Organisms

• US 20090163545A1
• Filed: 12/22/2008
• Published: 06/25/2009
• Est. Priority Date: 12/21/2007
• Status: Active Grant

• Current Assignee: University of Rochester
• Original Assignee: University of Rochester
• Inventors: Goldfarb, David Scott
• Granted Patent: US 8,642,660 B2
• Time in Patent Office: Days
• US Class Current: 514/312
• CPC Class Codes: A61K 31/122 having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
• CPC Class Codes: A61K 31/13 Amines A61K31/04 takes precedence
• CPC Class Codes: A61K 31/47 Quinolines; Isoquinolines
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

A method for altering the lifespan of a eukaryotic organism. The method comprises the steps of providing a lifespan altering compound, and administering an effective amount of the compound to a eukaryotic organism, such that the lifespan of the organism is altered. In one embodiment, the compound is identified using the DeaD assay.

Claims

1. ) A method for altering the lifespan of a eukaryotic organism comprising the steps of:

a) providing a lifespan altering compound having an EC50 of 10 μ

M or less and is selected from the group consisting of compounds 1-245 of Table 1; and

b) administering an effective amount of the compound to a eukaryotic organism, such that the lifespan of the eukaryotic organism is altered.

2. ) The method of claim 1, wherein the lifespan altering compound has an EC50 of 5 μ

M or less and is selected from the group consisting of compounds 1-77 of Table 1.

3. ) The method of claim 1, wherein the chemical structure of the lifespan altering compound comprises any one of the scaffolds of FIG. 6.

4. ) The method of claim 3, wherein the scaffold is selected from the group consisting of scaffold c1, c2, and c3.

5. ) The method of claim 4, wherein the scaffold is c1.

6. ) The method of claim 4, wherein the scaffold is c2.

7. ) The method of claim 4, wherein the scaffold is c3.

8. ) The method of claim 5, wherein the lifespan altering compound is selected from the group consisting of SID 14724551, SID 14732512, SID 7972147 and SID 17511642.

9. ) A method for altering the lifespan of a eukaryotic organism comprising the steps of:

a) providing a lifespan altering compound selected from the group consisting of the compounds listed in Table 2; and

b) administering an effective amount of the compound to a eukaryotic organism, such that the lifespan of the eukaryotic organism is altered.