BLOOD GLUCOSE SYSTEM HAVING TIME SYNCHRONIZATION

• US 20090163793A1
• Filed: 12/19/2008
• Published: 06/25/2009
• Est. Priority Date: 12/21/2007
• Status: Active Grant

• Current Assignee: Roche Diabetes Care Inc. (Roche Holding AG)
• Original Assignee: Roche Diabetes Care Inc. (Roche Holding AG)
• Inventors: Blasberg, Peter, Koehler, Matthias
• Granted Patent: US 10,169,540 B2
• Time in Patent Office: Days
• US Class Current: 600/365
• CPC Class Codes: A61B 5/0002 Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network A61B5/07 takes precedence; transmission systems for measured values G08C; transmission H04B; transmission of digital information H04L; wireless communication networks H04W
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: G16H 20/17 delivered via infusion or injection
• CPC Class Codes: G16H 40/63 for local operation
• CPC Class Codes: G16H 40/67 for remote operation
• CPC Class Codes: G16Z 99/00 Subject matter not provided for in other main groups of this subclass

Abstract

The present invention provides a blood glucose system for treating a glucose metabolic disorder. The system includes a dosing device having a counter for generating a count and memory for storing dose quantities and counts, a blood glucose measuring device having memory for storing blood glucose measurements and measurement times, and a data processor for receiving data from the dosing device and blood glucose measuring device and converting counts to actual times. The data processor synchronizes the counts with the measurement times using a time standard.

Claims

1. A blood glucose system for treating a glucose metabolic disorder, comprising:

a portable, independent ambulantly operable dosing device for delivering a medicinal agent for the treatment of the glucose metabolic disorder to a body, the dosing device including an integrated time counter for generating relative time values, a memory unit in which data sets of dosing quantities and associated time values are stored, and a device for transmitting stored data sets to a data processing apparatus;

a portable, independent ambulantly operable blood glucose measuring device for determining the blood glucose content of the body, the blood glucose measuring device including an integrated time standard, a memory unit in which data sets of blood glucose measurements and associated time values are stored, and a device for transmitting stored data sets to a data processing apparatus; and

a data processing apparatus for processing data sets of the dosing device and the blood glucose measuring device, the data processing apparatus having a receiving device for receiving the data sets from the dosing device and the blood glucose measuring device and an arithmetic unit for converting the time values of the data sets of the dosing device into absolute time values based on the comparison of the time value of the time counter of the dosing device to the time value of a time standard;

wherein, the data processing apparatus synchronizes the data sets of the dosing device and the data sets of the blood glucose measuring device with one another using the time value of the time standard by an assigned linkage.

2. The system of claim 1, wherein the dosing device is free from having an integrated time standard.

3. The system of claim 1, wherein the time values of the time standard of the blood glucose measuring device are used as time values for linking the data sets of the dosing device and the blood glucose measuring device.

4. The system of claim 1, wherein the data processing apparatus further comprises an integrated time standard, the time values of the time standard of the blood glucose measuring device or the time values of the time standard of the data processing apparatus are used as time values for linking the data sets of the dosing device and the blood glucose measuring device.

5. The system of claim 1, wherein the dosing device comprises an injection device or inhalation device.

6. The system of claim 1, wherein transmission of the data sets from the blood glucose measuring device or the dosing device to the data processing apparatus is performed using a cable connection or wirelessly.

7. The system of claim 1, wherein the data processing apparatus comprises a conversion unit which converts time values of the time counter of the dosing device into clock times.

8. A method for processing analysis results using a blood glucose system for treating a glucose anabolic disorder, the blood glucose system comprising a dosing device for delivering a medicinal agent for the treatment of the glucose metabolic disorder to a body and which comprises an integrated time counter for generating relative time values, a memory unit in which data sets of dosing quantities and associated time values are stored, and a device for transmitting stored data sets to a data processing apparatus, a blood glucose measuring device for determining the blood glucose content of the body and which comprises an integrated time standard, a memory unit in which data sets of blood glucose measurements and associated time values are stored, and a device for transmitting stored data sets to a data processing apparatus, and a data processing apparatus for processing data sets of the dosing device and the blood glucose measuring device and having a receiving device for receiving the data sets from the dosing device and the blood glucose measuring device and an arithmetic unit for converting the time values of the data sets of the dosing device into absolute time values on the basis of a comparison of the time value of the time counter of the dosing device to the time value of a time standard, wherein the data processing apparatus is implemented to synchronize the data sets of the dosing device and the data sets of the blood glucose measuring device with one another using the time value of the time standard by an assigned linkage, the method comprises:

storing one or more data sets of deliveries of a medicinal agent for the treatment of the glucose metabolic disorder in the dosing device, the data sets comprising dosing quantities and time values which were obtained using the integrated time counter at the instant of the particular delivery;

storing one or more data sets of blood glucose measurements in the blood glucose measurement device, the data sets containing analysis results and time values obtained from using the integrated time standard at the instant of each measurement,

transmitting one or more data sets of the blood glucose measuring device and the dosing device to the data processing apparatus and transferring the current time value of the time counter of the dosing device to the data processing apparatus;

calculating the absolute time values at which the agent was delivered by the dosing device using the data processing apparatus from the time values of the data set of the dosing device by comparing the current time value of the time counter of the dosing device to the time value of a time standard, the data sets of the dosing device and the blood glucose measuring device being synchronized with one another using the time value of the time standard by an assigned linkage; and

processing the dosing quantities and analysis results based on the calculated absolute time values.

9. The method of claim 8, wherein the time values of the time standard of the blood glucose measuring device are used as the time values for linking the data sets of the dosing device and the blood glucose measuring device.

10. The method of claim 8, wherein the data processing apparatus further comprises an integrated time standard, the time values of the time standard of the blood glucose measuring device or the data processing apparatus being used as the time standard for synchronizing and linking the data sets of the dosing device and the blood glucose measuring device with calculation of the time instants at which the agent was delivered by the dosing device.

11. The method of claim 8, wherein a time difference is ascertained from the time value of the time standard at a specific instant and the time value of the time counter at the same instant, whereby the time values of the data sets are converted into absolute time values by adding the time difference.

12. The method of claim 11, wherein, when stored data sets are transmitted from the dosing device to the data processing apparatus, the time difference between the time counter of the dosing device and the time standard is ascertained and the ascertained time difference is used immediately or at a later instant for correcting the time values of the data sets of the dosing device.

13. The method of claim 8, wherein, upon a first data transmission, a first time difference between the time standard and time counter is ascertained, and upon a subsequent second data transmission a corresponding second time difference is ascertained, such that time values lying between the first and second data transmissions are ascertained by interpolating between the first and second time differences and adding the interpolated time difference to the time value of the dose delivery.

14. The method of claim 8, wherein the step of processing dosing quantities and analysis results further comprises storing the data sets, transmitting the data sets to the data processing apparatus, or displaying the synchronized data sets of the dosing device and the blood glucose measuring device.

15. The method of claim 8, wherein the time counter counts using a predefined pulse rate and the calculation of the dosing time instants is calculated from the formula tA=tD−

(nD−

nA)/v.

16. The method of claim 8, wherein the duration of the dosing delivery is registered in the data set stored by the dosing device, such that the beginning and the end of a dosing delivery is marked in the data set of the dosing device at associated time values.

17. The method of claim 8, further comprising detecting whether a needle is located in a body during delivery of agent.

18. The method of claim 17, wherein the detecting step is performed by a needle sensor of the dosing device.

19. The method of claim 18, wherein the needle sensor comprises a priming sensor when a bolus is delivered without the needle being injected into the body, the bolus being used for priming the needle and the stored data set being marked.

20. A blood glucose system for treating a glucose metabolic disorder in a patient, comprising:

a dosing device for delivering an agent to a patient, the dosing device including a counter for generating a count and a dosing device memory for storing dosing quantities and counts;

a blood glucose measuring device having a blood glucose measuring device memory for storing blood glucose measurements and measurement times; and

a data processor for receiving data from the dosing device and the blood glucose measurement device and converting the counts to actual times.

21. The blood glucose system of claim 20, further comprising a clock which synchronizes the counts with the measurement times.

22. The blood glucose system of claim 21, wherein the clock is integrated within the blood glucose measuring device.

23. The blood glucose system of claim 21, wherein the data processor comprises the clock.

24. The blood glucose system of claim 20, wherein the dosing device and blood glucose measurement device wirelessly transmit data to the data processor.

25. The blood glucose system of claim 20, wherein the counter comprises a pulse generator.

26. The blood glucose system of claim 20, wherein the dosing device comprises an injection device or inhalation device.

27. The blood glucose system of claim 20, further comprising an adapter coupled to the data processor.

28. The blood glucose system of claim 27, wherein the adapter receives data from the dosing device and the blood glucose measuring device.

29. A method for processing data for treating a glucose metabolic disorder, comprising:

using a dosing device to deliver an agent to a patient;

recording a count associated with the agent delivery;

using a blood glucose measuring device to take and store a blood glucose measurement and store the measurement time of the blood glucose measurement; and

using a data processor to convert the count to an actual time of dosing.

30. The method of claim 29, further comprising using the data processor to synchronize the count with the measurement time.

31. The method of claim 30, further comprising using a clock to synchronize the count with the measurement time.

32. The method of claim 29, further comprising transmitting the count to the data processor.

33. The method of claim 29, further comprising transmitting the blood glucose measurement and measurement time to the data processor.

34. The method of claim 29, further comprising storing counts in a memory of the dosing device.

35. The method of claim 29, further comprising storing blood glucose measurements and measurement times in a memory of the blood glucose measuring device.

36. The method of claim 29, further comprising using a clock in the blood glucose measuring device or a clock in the data processor to convert the count to the actual time of dosing.