Coated Tissue Engineering Scaffold
First Claim
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1. A device comprisinga) a scaffold having one or more surfaces the scaffold comprising a plurality of fibers with outer surfaces and one or more void spaces defined by the outer surfaces of the fibers;
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Abstract
The invention concerns scaffolds comprising a coating on at least one surface that partially penetrates into the void spaces of the scaffold. The invention further concerns scaffolds comprising a partially penetrated anti-adhesion absorbable membrane layer.
95 Citations
25 Claims
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1. A device comprising
a) a scaffold having one or more surfaces the scaffold comprising a plurality of fibers with outer surfaces and one or more void spaces defined by the outer surfaces of the fibers; - and
b) a coating on at least one surface of the scaffold wherein the coating fills at least one void space. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 24, 25)
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23. The device of claim 23 wherein the cells are selected from the group consisting of osteocytes, osteoblasts, osteoclasts, fibroblasts, stem cells, pluripotent cells, chondrocyte progenitors, chondrocytes, endothelial cells, macrophages, leukocytes, adipocytes, monocytes, plasma cells, mast cells, umbilical cord cells, placental cells, stromal cells, epithelial cells, myoblasts, tenocytes, ligament fibroblasts, neurons, bone marrow cells, synoviocytes, precursor cells derived from adipose tissue, peripheral blood progenitor cells, genetically transformed cells, precursor cells isolated from adult tissue and combinations thereof.
Specification