METHOD AND APPARATUS FOR MEASURING ANALYTES
First Claim
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1. A device for measuring a concentration of one or more than one compound in a sample, comprising:
- a source of electromagnetic radiation (EMR) that emits one or more than one wavelength of EMR, the source of EMR being operatively coupled to a power source;
a holder for receiving a detachable receptor, the holder comprising one or more than one input in operable association with the source of EMR, one or more than one output in operable association with a detector, the one or more than one input and the one or more than output of the holder in optical alignment with one or more than one port located within the receptor, the one or more than one input and the one or more than output defining an EMR path through the holder and within the receptor, wherein, the sample when received by the receptor is placed within the EMR path;
the detector for measuring transmitted or reflected EMR received from the sample, the detector operatively coupled to a processing system;
the processing system comprising one, or more than one calibration algorithm for determining a concentration for the one or more than one compound.
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Abstract
A method for measuring the concentration of a compound in the blood of a part of a subject is provided. An invasive or non-invasive sample of blood may be used for this determination. Also provided is a device for measuring the concentration of a compound in the blood of a subject. The device comprises a source of electromagnetic radiation, a holder, a detector and a processing system.
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Citations
39 Claims
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1. A device for measuring a concentration of one or more than one compound in a sample, comprising:
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a source of electromagnetic radiation (EMR) that emits one or more than one wavelength of EMR, the source of EMR being operatively coupled to a power source; a holder for receiving a detachable receptor, the holder comprising one or more than one input in operable association with the source of EMR, one or more than one output in operable association with a detector, the one or more than one input and the one or more than output of the holder in optical alignment with one or more than one port located within the receptor, the one or more than one input and the one or more than output defining an EMR path through the holder and within the receptor, wherein, the sample when received by the receptor is placed within the EMR path; the detector for measuring transmitted or reflected EMR received from the sample, the detector operatively coupled to a processing system; the processing system comprising one, or more than one calibration algorithm for determining a concentration for the one or more than one compound. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 28, 29, 30)
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11. A method of determining the concentration of one or more than one compound in a sample of blood comprising,
(a) placing a receptor over a portion of a body part, the body part having a sample of blood thereon, (b) directing a source of electromagnetic radiation (EMR) through the receptor and onto the sample of blood; -
(c) measuring a quantity of the EMR reflected by, or transmitted through, the sample of blood with a detector; and (d) performing a quantitative mathematical analysis of the quantity of EMR using an algorithm, and determining the concentration of the one or more than one compound in the sample of blood. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20, 31, 32, 33)
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21. A method of determining the concentration of one or more than one compound in a sample of blood comprising,
(a) placing a receptor over a portion of a body part; -
(b) lancing the body part located within the receptor to produce a sample of blood on the surface of the body part, (c) directing a source of electromagnetic radiation (EMR) through the receptor and onto the sample of blood; (d) measuring a quantity of the EMR reflected by, or transmitted through, the sample of blood with a detector; and (e) performing a quantitative mathematical analysis of the quantity of EMR using an algorithm, and determining the concentration of the one or more than one compound in the sample of blood. - View Dependent Claims (22, 23, 24, 25, 26, 27, 34, 35, 36)
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37. A method of determining the concentration of one or more than one compound in a sample comprising,
(a) placing a receptor over a portion of a body part, and either (i) directing a source of electromagnetic radiation (EMR) through the receptor and the body part; -
(ii) lancing the body part to obtain sample of blood and directing the source of electromagnetic radiation (EMR) through the receptor and the sample of blood;
or(iii) directing the source of electromagnetic radiation (EMR) through the receptor and the body part, and lancing the body part to obtain sample of blood and directing the source of electromagnetic radiation (EMR) through the receptor and the sample of blood; (b) measuring a quantity of the EMR reflected by, or transmitted through, the body part, sample of blood, or both the body part and the sample of blood with a detector; and (c) performing a quantitative mathematical analysis of the quantity of EMR using an algorithm, and determining the concentration of the one or more than one compound in the body part, the sample of blood, or both the body part and the sample of blood, wherein the one or more than one compound may be selected from the group consisting of a neutral or ionic form of a heavy metal having an atomic number greater than 20. - View Dependent Claims (38, 39)
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Specification