MICROFLUIDIC PROTEIN CRYSTALLOGRAPHY
First Claim
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1. An apparatus for investigating crystallization comprising:
- a microfluidic formulator comprising a microfluidic chamber configured to receive a crystallization target and a precipitant;
a light source configured to illuminate the microfluidic chamber; and
a light detector configured to receive light transmitted through the microfluidic chamber.
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Abstract
The use of microfluidic structures enables high throughput screening of protein crystallization. In one embodiment, an integrated combinatoric mixing chip allows for precise metering of reagents to rapidly create a large number of potential crystallization conditions, with possible crystal formations observed on chip. In an alternative embodiment, the microfluidic structures may be utilized to explore phase space conditions of a particular protein crystallizing agent combination, thereby identifying promising conditions and allowing for subsequent focused attempts to obtain crystal growth.
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Citations
9 Claims
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1. An apparatus for investigating crystallization comprising:
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a microfluidic formulator comprising a microfluidic chamber configured to receive a crystallization target and a precipitant; a light source configured to illuminate the microfluidic chamber; and a light detector configured to receive light transmitted through the microfluidic chamber. - View Dependent Claims (2, 3, 4, 5, 6)
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7. An apparatus for investigating crystallization comprising:
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a chip holder for holding a microfluidic chamber configured to receive a crystallization target and a precipitant; a light source configured to illuminate the microfluidic chamber; and a light detector configured to receive light transmitted through the microfluidic chamber. - View Dependent Claims (8, 9)
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Specification