TREATMENT OF INTERVERTEBRAL DISC DEGENERATION USING HUMAN UMBILICAL CORD TISSUE-DERIVED CELLS
First Claim
1. A method of treating a disease or condition related to intervertebral disc degeneration, comprising administering cells obtained from human umbilical cord tissue to an intervertebral disc in an amount effective to treat the disease or condition, wherein the umbilical cord tissue is substantially free of blood, and wherein the cells:
- are capable of self-renewal and expansion in culture and have the potential to differentiate;
require L-valine for growth;
can grow in at least about 5% oxygen.
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Abstract
Methods for treating a patient having a disease or condition related to IVD degeneration are provided. The methods comprise administering cells obtained from human umbilical cord tissue, or administering pharmaceutical compositions comprising such cells or prepared from such cells. In some embodiments, administering the cells promotes repair and regeneration of degenerated IVD tissue in the patient. Pharmaceutical compositions for use in the inventive methods, as well as kits for practicing the methods are also provided.
81 Citations
28 Claims
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1. A method of treating a disease or condition related to intervertebral disc degeneration, comprising administering cells obtained from human umbilical cord tissue to an intervertebral disc in an amount effective to treat the disease or condition, wherein the umbilical cord tissue is substantially free of blood, and wherein the cells:
- are capable of self-renewal and expansion in culture and have the potential to differentiate;
require L-valine for growth;
can grow in at least about 5% oxygen. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
- are capable of self-renewal and expansion in culture and have the potential to differentiate;
Specification