Methods and Compositions for Controlled and Sustained Production and Delivery of Peroxides and/or Oxygen for Biological and Industrial Applications

• US 20090169630A1
• Filed: 05/14/2007
• Published: 07/02/2009
• Est. Priority Date: 05/15/2006
• Status: Abandoned Application

• Current Assignee: Virginia Commonwealth University
• Original Assignee: Virginia Commonwealth University
• Inventors: Huvard, Gary, Sandhu, Gurbhagat, Spiess, Bruce, Carpenter, Everette, Barbee, Robert, Ward, Kevin
• Application Number:
  US12/226,945
• Publication Number:
  US 20090169630A1
• Time in Patent Office: Days
• US Class Current: 424/489
• CPC Class Codes: A01N 2300/00 Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
• CPC Class Codes: A01N 25/02 containing liquids as carriers, diluents or solvents
• CPC Class Codes: A01N 25/30 characterised by the surfactants
• CPC Class Codes: A01N 27/00 Biocides, pest repellants or attractants, or plant growth regulators containing hydrocarbons
• CPC Class Codes: A01N 59/00 Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
• CPC Class Codes: A01N 59/16 Heavy metals; Compounds thereof
• CPC Class Codes: A01N 59/20 Copper
• CPC Class Codes: A61K 31/17 having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine isoureas, isothioureas A61K31/155; sulfonylureas A61K31/64
• CPC Class Codes: A61K 33/40 Peroxides
• CPC Class Codes: A61K 47/06 Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
• CPC Class Codes: A61K 9/5031 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
• CPC Class Codes: A61L 2/0082 using chemical substances
• CPC Class Codes: A61L 2/0088 Liquid substances
• CPC Class Codes: A61L 2/186 Peroxide solutions
• CPC Class Codes: A61L 2/23 Solid substances, e.g. granules, powders, blocks, tablets
• CPC Class Codes: A61L 2202/24 Medical instruments, e.g. endoscopes, catheters, sharps
• CPC Class Codes: A61P 17/02 for treating wounds, ulcers, burns, scars, keloids, or the like
• CPC Class Codes: A61P 39/00 General protective or antinoxious agents
• CPC Class Codes: C01B 13/0211 Peroxy compounds
• CPC Class Codes: C01B 15/03 Preparation from inorganic peroxy compounds, e.g. from peroxysulfates
• CPC Class Codes: C01B 15/032 : from metal peroxides
• CPC Class Codes: C02F 1/722 : Oxidation by peroxides

Abstract

Methods and compositions for the controlled and sustained release of peroxides or oxygen to aqueous environments (e.g. a patient'"'"'s body or circulatory system, or for other applications) or non-aqueous environments, include a material coating or encapsulating hydrogen peroxide, inorganic peroxides or peroxide adducts. In the case of peroxide adducts, and particularly in one type of embodiment, the peroxide adducts should be able to permeate the material, but water, hydrogen peroxide and inorganic peroxides should be able to permeate the material. The methods and compositions that allow the release of oxygen, H₂O₂ or inorganic peroxides from peroxide adducts with movement of these moieties across a selectively permeable barrier into, preferably, an aqueous environment. In the case of hydrogen peroxide, it can be acted upon by catalase or other enzymes, or be simply degraded, or are otherwise acted upon by enzymes or catalysts embedded in the selectively permeable barrier to produce, for example, O₂. Alternatively, hydrogen peroxide or inorganic peroxides can be delivered selectively to a site of action of cleaning, disinfecting or other applications.

Claims

1-45. -45. (canceled)

46. A composition comprising a peroxide or oxygen producing compound together with a hydrophobic liquid or hydrophobic material.

47. The composition of claim 46 wherein said hydrophobic liquid or hydrophobic material is selected from the group consisting of chlorocarbons, hydrofluorocarbons, hydrochlorofluorocarbons, olefinic waxes and oils, microcrystalline waxes, silicone oils, waxes and gels, perfluorocarbons, hydrocarbons, polyethylene glycols (PEGs), ethyl acetate, cod liver oil, glyceryl triacetate, blood substitutes, and hydrophobic solvents.

48. The composition of claim 46 wherein said hydrophobic liquid or material is selected from the group consisting of olefinic, styryl, and vinyl polymers, polyamides, polyesters, polyurethanes, polycarbamates, poly ether ether ketones, silicon polymers, polysilanes, fluoropolymers, olefinic and polyethelyene waxes, animal fats or lipids, and gels made by dissolving polymers in hydrophobic solvents.

49. The composition of claim 46 further comprising a membrane or coating material which covers said peroxide or oxygen producing compound slurried together with said hydrophobic liquid or material, wherein said membrane or coating material permits water, hydrogen peroxide, and oxygen to pass therethrough, but prevents or delays a rate of transport of said peroxide or oxygen producing compound slurried together with said hydrophobic liquid or material through said membrane or coating material.

50. The composition of claim 49 further comprising a catalyst embedded in or associated with said membrane or coating material.

51. The composition of claim 50 wherein said catalyst includes iron or copper.

52. The composition of claim 50 wherein said catalyst includes catalase.

53. The composition of claim 46 further comprising a substrate having a hydrophobic surface or region, wherein said peroxide or oxygen producing compound slurried together with said hydrophobic liquid or material is associated with said hydrophobic surface or region.

54. The composition of claim 53 wherein said substrate is a bandage or wound care device.

55. The composition of claim 46, wherein the peroxide or oxygen producing compound is in the form of particles, which particles are slurried together with a perfluorocarbon or other hydrophobic liquid.

56. The composition of claim 55 wherein said particles have a mean diameter of less than 10μ

.

57. The composition of claim 46 wherein said peroxide or oxygen producing compound is freeze dried hydrogen peroxide.

58. The composition of claim 46 wherein said peroxide or oxygen producing compound is an inorganic peroxide.

59. The composition of claim 46 wherein said peroxide or oxygen producing compound is a peroxide adduct.

60. The composition of claim 59, wherein the peroxide adduct is slurried together with a perfluorocarbon.

61. The composition of claim 60 wherein the peroxide adduct is selected from sodium carbonate perhydrate, histadine hydrogen peroxide, adenine hydrogen peroxide, urea hydrogen peroxide, and alkaline peroxyhydrates.

62. The composition of claim 60 wherein said perfluorocarbon is perfluorodeclin.

63. The composition of claim 46 further comprising a membrane or coating material which covers said peroxide adduct slurried together with said perfluorocarbon, wherein said membrane or coating material permits water, hydrogen peroxide, and oxygen to pass therethrough, but prevents or delays a rate of transport of said peroxide adduct slurried together with said perfluorocarbon through said membrane or coating material.

64. A method of providing oxygen to a patient (human or animal) in need thereof, comprising the steps of:

administering to said patient an oxygen producing or hydrogen peroxide producing composition encapsulated in or coated with a material which is permeable to water, and hydrogen peroxide and oxygen, and which prevents or reduces the transport of said oxygen producing or hydrogen peroxide producing composition therethrough;

permitting water or an aqueous fluid to pass through said material and to contact said oxygen producing or hydrogen peroxide producing composition; and

permitting oxygen or hydrogen peroxide generated by a reaction of said water or aqueous fluid and said oxygen producing or hydrogen peroxide producing composition to pass through said material to come into contact with said patient or a device associated with said patient and, selectively, catalytically converting hydrogen peroxide to oxygen.

65. A method of providing hydrogen peroxide, inorganic peroxide, or oxygen to an environment of interest, comprising the steps of:

positioning a composition comprising a peroxide adduct, inorganic peroxide, or freeze dried hydrogen peroxide slurried together with a hydrophobic liquid or material in proximity to or communication with an environment in which hydrogen peroxide, inorganic peroxide, or oxygen is desired; and

exposing said composition to water or aqueous fluid so as to generate one or more of hydrogen peroxide, inorganic peroxide, or oxygen from said composition.