FUNCTIONALIZED PHENOLIC COMPOUNDS AND POLYMERS THEREFROM
First Claim
Patent Images
1. A compound of formula I or a pharmaceutically acceptable salt thereof:
-
Ar—
[O—
(X)p—
R′
]q
Iwherein;
Ar—
(O)q is a phenolic residue;
X is independently at each occurrence selected from;
—
CH2COO—
;
—
CH(CH3)COO—
;
—
CH2CH2OCH2COO—
;
—
CH2CH2CH2CH2CH2COO—
;
—
(CH2)yCOO—
; and
, —
(CH2CH2O)zCH2COO—
, where y is independently selected from 2,3,4 and 6-24 and z is independently selected from 2-24;
R′
is selected from H, benzyl, and C1-6 alkyl;
p is independently selected from 0, 1, 2, 3, and 4; and
,q is selected from 1-10;
provided that at least one X is present; and
,further provided that when X is solely —
CH2COO—
or —
CH(CH3)COO—
or —
CH2CH2CH2CH2CH2COO— and
q is 1 or 2, then p is ≧
2.
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Abstract
The present invention relates to compounds of formula I, which are functionalized phenolic compounds, and polymers formed from the same.
Ar—[O—(X)p—R′]q I
Polymers formed from the functionalized phenolics are expected to have controllable degradation profiles, enabling them to release an active component over a desired time range. The polymers are also expected to be useful in a variety of medical applications.
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Citations
62 Claims
-
1. A compound of formula I or a pharmaceutically acceptable salt thereof:
-
Ar—
[O—
(X)p—
R′
]q
Iwherein; Ar—
(O)q is a phenolic residue;X is independently at each occurrence selected from;
—
CH2COO—
;
—
CH(CH3)COO—
;
—
CH2CH2OCH2COO—
;
—
CH2CH2CH2CH2CH2COO—
;
—
(CH2)yCOO—
; and
, —
(CH2CH2O)zCH2COO—
, where y is independently selected from 2,3,4 and 6-24 and z is independently selected from 2-24;R′
is selected from H, benzyl, and C1-6 alkyl;p is independently selected from 0, 1, 2, 3, and 4; and
,q is selected from 1-10; provided that at least one X is present; and
,further provided that when X is solely —
CH2COO—
or —
CH(CH3)COO—
or —
CH2CH2CH2CH2CH2COO— and
q is 1 or 2, then p is ≧
2. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
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29. A polymer, comprising:
- a functionalized phenolic of formula I;
Ar—
[O—
(X)p—
R′
]q
Iwherein; Ar—
(O)q is a phenolic residue;X is independently at each occurrence selected from;
—
CH2COO—
;
—
CH(CH3)COO—
;
—
CH2CH2OCH2COO—
;
—
CH2CH2CH2CH2CH2COO—
;
—
(CH2)yCOO—
; and
, —
(CH2CH2O)zCH2COO—
, where y is independently selected from 2, 3, 4 and 6-24 and z is independently selected from 2-24;R′
is selected from H, benzyl, and C1-6 alkyl;p is independently selected from 0, 1, 2, 3, and 4; and
,q is selected from 1-10; provided that at least one X is present; and
,further provided that when Ar—
[O]q is hydroxy benzene, then (X)p is other than —
CH2COO—
or —
CH2CH2CH2CH2CH2COO—
. - View Dependent Claims (30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62)
- a functionalized phenolic of formula I;
Specification