Catheter-Based, Dual Balloon Photopolymerization System

• US 20090171265A1
• Filed: 02/02/2009
• Published: 07/02/2009
• Est. Priority Date: 06/23/2005
• Status: Active Grant

• Current Assignee: Medtronic Vascular, Inc. (Medtronic Plc)
• Original Assignee: Medtronic Vascular, Inc. (Medtronic Plc)
• Inventors: Doty, David, Kilari, Prasad, Murray, Robret, Wilcox, Josiah, Ozdil, Feridun
• Granted Patent: US 7,912,539 B2
• Time in Patent Office: Days
• US Class Current: 604/21
• CPC Class Codes: A61B 17/12045 double occlusion, e.g. during anastomosis
• CPC Class Codes: A61B 17/12109 in a blood vessel
• CPC Class Codes: A61B 17/12136 Balloons
• CPC Class Codes: A61B 2017/12127 Double occlusion, e.g. for creating blood-free anastomosis site
• CPC Class Codes: A61B 2017/22085 light-absorbing A61B2017/22087 takes precedence
• CPC Class Codes: A61M 2025/09008 having a balloon
• CPC Class Codes: A61M 2025/1052 for temporarily occluding a vessel for isolating a sector
• CPC Class Codes: A61M 25/1011 Multiple balloon catheters
• CPC Class Codes: A61N 5/0601 Apparatus for use inside the body
• CPC Class Codes: A61N 5/062 Photodynamic therapy, i.e. excitation of an agent

Abstract

A system for applying a polymer (hydrogel) to the inner surface of a vessel by photopolymerization includes a catheter having a first inflatable member and a guidewire having a second inflatable member. The catheter has an extended tip distal to the first inflatable member that includes multiple perfusion ports. A light emission coil is disposed on the extended tip with individual coil loops interspaced with the perfusion ports. In a method, the guidewire is delivered to a treatment site within a vessel. The catheter is delivered to the treatment site over the guidewire. The inflatable members are inflated to form an enclosed treatment space within the vessel. A photoinitiator is delivered to the enclosed treatment space. Excess photoinitiator is flushed from the treatment space, and a prepolymer is delivered. The prepolymer is cured by light delivered by the light emission coil.

Claims

1-19. -19. (canceled)

20. A method of treating a vascular condition, the method comprising:

delivering a guidewire to a treatment site within a vessel, the guidewire including a first expandable member;

delivering a catheter over the guidewire to the treatment site, the catheter including a second expandable member;

expanding the first and second expandable members to form an enclosed treatment space within the vessel;

delivering a fluid to the treatment space; and

exposing the treatment space to light.

21. The method of claim 20 wherein expanding the first and second expandable members to form an enclosed treatment space within the vessel comprises:

first expanding the second expandable member; and

then expanding the first expandable member.

22. The method of claim 20 further comprising:

flushing the treatment space with a flushing solution after delivering the fluid to the helical cavity.

23. The method of claim 22 further comprising:

delivering a second fluid to the treatment space after flushing the treatment space with a flushing solution.

24. The method of claim 23 wherein the second fluid is a prepolymer.

25. The method of claim 24 wherein exposing the treatment space to light comprises photopolymerizing at least a portion of the prepolymer to form a polymer coating on the inner wall of the vessel.

26. The method of claim 20 wherein the treatment space is exposed to light along a helical path.

27. The method of claim 20 wherein the treatment space is exposed to light along multiple longitudinal paths.