TUNABLE NANOPARTICLE TAGS TO ENHANCE TISSUE RECOGNITION
First Claim
1. A method of locating and ablating a target tissue, the method comprising:
- providing a catheter comprising at least one light guide, wherein the light guide is adaptable to receive light from a light source;
advancing a distal portion of the catheter through vasculature of a patient towards the target tissue;
introducing a nanoparticle dye into the patient, wherein the nanoparticle dye selectively binds to the target tissue;
mapping the target tissue by detecting fluorescence light emitted from the nanoparticle dye bound to the tissue;
positioning the distal tip of the catheter adjacent to the imaged target tissue; and
transmitting a light pulse through the light guide to ablate at least a portion of the target tissue.
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Accused Products
Abstract
A method of locating and ablating a target tissue is described. The method includes providing a catheter that has at least one light guide, where the light guide is adaptable to receive light from a light source. A distal portion of the catheter is advanced through vasculature of a patient towards the target tissue. A nanoparticle dye is introduced into the patient, where the nanoparticles selectively bind to the target tissue. The target tissue is mapped by detecting fluorescence light emitted from the nanoparticle dye bound to the tissue. The distal tip of the catheter is positioned adjacent to the mapped target tissue, and a light pulse is transmitted through the light guide to ablate at least a portion of the target tissue.
25 Citations
28 Claims
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1. A method of locating and ablating a target tissue, the method comprising:
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providing a catheter comprising at least one light guide, wherein the light guide is adaptable to receive light from a light source; advancing a distal portion of the catheter through vasculature of a patient towards the target tissue; introducing a nanoparticle dye into the patient, wherein the nanoparticle dye selectively binds to the target tissue; mapping the target tissue by detecting fluorescence light emitted from the nanoparticle dye bound to the tissue; positioning the distal tip of the catheter adjacent to the imaged target tissue; and transmitting a light pulse through the light guide to ablate at least a portion of the target tissue. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A method of locating and ablating a target tissue, the method comprising:
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providing a catheter comprising a plurality of light guides, wherein at least a portion of the light guides are adaptable to receive light from an ablation light source and a fluorescence light source; advancing a distal portion of the catheter through vasculature of a patient towards the target tissue; introducing the nanoparticle dye into the patient, wherein the nanoparticle dye selectively binds to the target tissue; irradiating the target tissue with excitation light transmitted from the fluorescence light source through the light guides and detecting the fluorescence emitted from the nanoparticle dye bound to the tissue to map the target tissue; positioning the distal tip of the catheter adjacent to the mapped target tissue; and transmitting ablation light from the ablation light source through the light guides to ablate at least a portion of the target tissue. - View Dependent Claims (16, 17, 18, 19)
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20. A catheter and dye kit having component parts capable of being assembled to ablate target tissue in a patient, the kit comprising:
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a catheter comprising a plurality of light guides, wherein a proximal end of the light guides are adaptable to a light source; a container that holds a nanoparticle dye; and instructions for advancing a distal portion of the catheter through vasculature of the patient towards the target tissue; introducing the nanoparticle dye into the patient, wherein the nanoparticle dye selectively binds to the target tissue; mapping the target tissue by detecting fluorescence light emitted from the nanoparticle dye bound to the tissue; positioning the distal tip of the catheter adjacent to the mapped target tissue; and transmitting a light pulse through the light guides to ablate at least a portion of the target tissue. - View Dependent Claims (21, 22, 23, 24, 25, 26, 27, 28)
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Specification