BIVALENT, BISPECIFIC ANTIBODIES
First Claim
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1. A bivalent, bispecific antibody, comprising:
- a) the light chain and heavy chain of an antibody specifically binding to a first antigen, wherein heavy chain domain CH3 of the antibody specifically binding to a first antigen is replaced by a constant heavy chain domain CH1;
b) the light chain and heavy chain of an antibody specifically binding to a second antigen, wherein constant heavy chain domain CH3 of the antibody specifically binding to a second antigen is replaced by a constant light chain domain CL.
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Abstract
The present invention relates to novel domain exchanged, bivalent, bispecific antibodies, their manufacture and use.
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Citations
8 Claims
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1. A bivalent, bispecific antibody, comprising:
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a) the light chain and heavy chain of an antibody specifically binding to a first antigen, wherein heavy chain domain CH3 of the antibody specifically binding to a first antigen is replaced by a constant heavy chain domain CH1; b) the light chain and heavy chain of an antibody specifically binding to a second antigen, wherein constant heavy chain domain CH3 of the antibody specifically binding to a second antigen is replaced by a constant light chain domain CL. - View Dependent Claims (2, 3, 5, 6, 7, 8)
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4. A host cell comprising:
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vectors comprising nucleic acid molecules encoding the light chain and heavy chain of an antibody specifically binding to a first antigen, wherein the heavy chain domain CH3 of the antibody specifically binding to a first antigen is replaced by a constant heavy chain domain CH1; and vectors comprising nucleic acid molecules encoding the light chain and heavy chain of an antibody specifically binding to a second antigen, wherein the constant heavy chain domain CH3 of the antibody specifically binding to a second antigen is replaced by a constant light chain domain CL.
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Specification