MATERIALS AND METHODS FOR TREATMENT OF INFLAMMATORY AND CELL PROLIFERATION DISORDERS
First Claim
1. A method of treating or reducing the onset of an inflammatory or cell proliferation disorder, comprising administering a natriuretic hormone peptide (NP), or a polynucleotide encoding NP and an operably-linked promoter sequence, to a patient in need thereof.
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Abstract
The present invention pertains to methods for treatment of inflammatory and cell proliferation disorders, such as cancer, by administering an agent that reduces atrial natriuretic peptide receptor-A (NPR-A) activity. In one aspect, the invention concerns a method for treatment of inflammatory and cell proliferation disorders, such as cancer, by administration of an effective amount of natriuretic hormone peptide (NP), or a polynucleotide encoding NP and an operably-linked promoter sequence. In another aspect, the present invention includes a pharmaceutical composition comprising an agent that reduces the activity of atrial natriuretic peptide receptor-A (NPR-A), and an anti-cancer agent. In another aspect, the present invention further concerns a method for identifying an agent useful for treating an inflammatory or cell proliferation disorder, comprising determining whether the agent reduces the activity of atrial natriuretic peptide receptor-A (NPR-A).
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19 Claims
- 1. A method of treating or reducing the onset of an inflammatory or cell proliferation disorder, comprising administering a natriuretic hormone peptide (NP), or a polynucleotide encoding NP and an operably-linked promoter sequence, to a patient in need thereof.
- 14. A method for reducing the activity of atrial natriuretic peptide receptor-A (NPR-A) in cells in vitro or in vivo, comprising administering an effective amount of an agent that reduces NPR-A activity to the cells.
- 17. A pharmaceutical composition comprising an agent that reduces the activity of atrial natriuretic peptide receptor-A (NPR-A), and an anti-cancer agent.
Specification